Scopus
🔓 Açık Erişim
Qualitative chemical characterization and multidirectional biological investigation of leaves and bark extracts of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae)
Antioxidants · Eylül 2019
Makale Bilgileri
DergiAntioxidants
Yayın TarihiEylül 2019
Cilt / Sayfa8
Scopus ID2-s2.0-85073330443
Erişim🔓 Açık Erişim
Özet
Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) has a long history of use by folk populations for the management of multiple human ailments. Based on the published literature, there has been no attempt to conduct a comparative assessment of the biological activity and the phytochemical profiles of the leaves and stem bark of A. leiocarpus extracted using methanol, ethyl acetate, and water. By high-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MSn) analysis, quinic, shikimic, gallic, and protocatechuic acids were tentatively identified from all the extracts, while chlorogenic, caffeic, ferulic, and dodecanedioic acids were only characterised from the leaves extracts. Additionally, a pharmacological study was carried out to evaluate potential protective effects that are induced by the extracts in rat colon and colon cancer HCT116 cell line. In general, the methanol and water extracts of A. leiocarpus leaves and stem bark showed potent radical scavenging and reducing properties. It was noted that the stem bark extracts were more potent antioxidants as compared to the leaves extracts. The methanol extract of A. leiocarpus leaves showed the highest acetyl (4.68 mg galantamine equivalent/g) and butyryl (4.0 mg galantamine equivalent/g) cholinesterase inhibition. Among ethyl acetate extracts, the pharmacological investigation suggested stem bark ethyl acetate extracts to be the most promising. This extract revealed ability to protect rat colon from lipopolysaccharide-induced oxidative stress, without exerting promoting effects on HCT116 cell line viability and migration. As a conclusion, A. leiocarpus represents a potential source of bioactive compounds in the development of novel therapeutic agents.
Yazarlar (16)
1
Giustino Orlando
2
Claudio Ferrante
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Kouadio Ibrahime Sinan
5
Kouadio Bene
6
Alina Diuzheva
ORCID: 0000-0003-2090-1634
7
József Jekő
8
Zoltán Cziáky
9
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
10
Lucia Recinella
11
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
12
Sheila Leone
13
Luigi Brunetti
14
Carene Marie Nancy Picot-Allain
15
Mohamad Fawzi Mahomoodally
16
Luigi Menghini
ORCID: 0000-0002-7346-7395
Anahtar Kelimeler
Anogeissus
Antioxidant
Bioactive compounds
Enzyme inhibition
Ulcerative colitis
Kurumlar
Czech University of Life Sciences Prague
Prague Czech Republic
Selçuk Üniversitesi
Selçuklu Turkey
Université d'Abobo-Adjamé
Abidjan Cote d'Ivoire
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
University of Nyíregyháza
Nyíregyháza Hungary
Metrikler
16
Atıf
16
Yazar
5
Anahtar Kelime