Scopus
Multiple pharmacological approaches on hydroalcoholic extracts from different parts of Cynoglossum creticum Mill. (Boraginaceae)
Plant Biosystems · Eylül 2019
Makale Bilgileri
DergiPlant Biosystems
Yayın TarihiEylül 2019
Cilt / Sayfa153 · 633-639
Scopus ID2-s2.0-85057542202
Özet
Cynoglossum creticum Mill (Boraginaceae) is used traditionally as a remedy to manage several human ailments. In this context, the present study aimed to perform multiple pharmacological investigations on the hydroalcoholic extracts prepared from Cynoglossum roots and aerial parts (leaves and flowers). We evaluated the antioxidant and enzyme inhibitory (against cholinesterases, α-glucosidase, α-amylase, lipase and tyrosinase) activity of the extracts. The protective effect(s) of the extracts on cardiomyocyte C2C12 and intestinal HCT116 cell lines challenged with hydrogen peroxide (H2O2) was studied. We found that the aerial parts harbored the highest amount of phenolic compounds. Generally, aerial parts showed significant antioxidant and enzyme inhibitory effects. Leaves exhibited the best lipase inhibitory activity (173.15 mgOE/g extract), followed by flowers and roots. The root and aerial extracts were equally able to blunt intracellular H2O2 induced reactive oxygen species production from both C2C12 and HCT116 cell lines. Both cells lines could be treated with scalar concentrations of root and flower extracts in the range 50–300 μg/mL without interferences on cell viability. In conclusion, the present study showed protective effects exerted by Cynoglossum extracts, which could serve as a foundation for the development of pharmaceuticals and nutraceuticals derived from Cynoglossum.
Yazarlar (12)
1
Luigi Menghini
ORCID: 0000-0002-7346-7395
2
Claudio Ferrante
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Mohamad Fawzi Mahomoodally
5
Lidia Leporini
6
Marcello Locatelli
ORCID: 0000-0002-0840-825X
7
Francesco Cacciagrano
8
Lucia Recinella
9
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
10
Sheila Leone
11
Luigi Brunetti
12
Giustino Orlando
Anahtar Kelimeler
antioxidant
cardiomyocyte
cell assays
Cynoglossum
enzyme inhibition
HPLC-PDA
natural agents
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Metrikler
8
Atıf
12
Yazar
7
Anahtar Kelime