Scopus
New pharmacological targets of three Asphodeline species using in vitro and ex vivo models of inflammation and oxidative stress
International Journal of Environmental Health Research · Eylül 2019
Makale Bilgileri
DergiInternational Journal of Environmental Health Research
Yayın TarihiEylül 2019
Cilt / Sayfa29 · 520-530
Scopus ID2-s2.0-85058093540
Özet
This study explored the efficacy of the methanolic extract of three Asphodeline species (A. damascena subsp. rugosa, A. tenuior subsp. tenuiflora var. tenuiflora, and A. cilicica) to protect against hydrogen peroxide (H2O2)-induced lactate dehydrogenase (LDH) activity in HCT116 cells, and also any protective effects against lipopolysaccharides (LPS)-induced nitrite levels, prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2α (8-iso-PGF2α) levels, 5HIAA/5-HT ratio, tumor necrosis factor (TNF)-α and interleukin (IL)-6 gene expression in rat colon specimens. Interestingly, A. tenuior extract was most effective in improving the tested biomarkers, by reducing LDH activity and nitrite level. On the other hand, A. damascena was the only species able to blunt LPS-induced TNF-α gene expression in rat colon specimens. The present findings highlighted the protective effects of Asphodeline extracts via in vitro and ex vivo models of inflammation and oxidative stress, adding new insights to the pharmacological actions of these medicinal plant species. Abbreviations: IBD: inflammatory bowel disease; LPS: lipopolysaccharide; LDH: lactate dehydrogenase; 5HIAA: 5-hydroxyindoleacetic acid; 5-HT: 5-hydroxytryptamine.
Yazarlar (12)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Marcello Locatelli
ORCID: 0000-0002-0840-825X
3
Claudio Ferrante
4
Luigi Menghini
ORCID: 0000-0002-7346-7395
5
Giustino Orlando
6
Luigi Brunetti
7
Lucia Recinella
8
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
9
Sheila Leone
10
Lidia Leporini
11
Muhammad Zakariyyah Aumeeruddy
12
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Asphodeline
inflammation
natural agents
oxidative stress
pharmaceutical applications
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Metrikler
4
Atıf
12
Yazar
5
Anahtar Kelime