Scopus
YÖKSİS Eşleşti
Influence of different extraction techniques on the chemical profile and biological properties of Anthemis cotula L.: Multifunctional aspects for potential pharmaceutical applications
Journal of Pharmaceutical and Biomedical Analysis · Eylül 2019
YÖKSİS Kayıtları
Influence of different extraction techniques on the chemical profile and biological properties of Anthemis cotula L.: Multifunctional aspects for potential pharmaceutical applications
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2019 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiJournal of Pharmaceutical and Biomedical Analysis
Yayın TarihiEylül 2019
Cilt / Sayfa173 · 75-85
Scopus ID2-s2.0-85065717769
Özet
The phytochemical composition of different extracts obtained from stinking chamomile (Anthemis cotula L.)was investigated. Ethanol was used as solvent and accelerated solvent extraction (ASE), microwave assisted extraction (MAE), maceration, soxhlet extraction (SE), and ultrasound assisted extraction (UAE)were applied on plant material. Comparison of the phytochemical contents, antioxidant, and enzyme inhibitory properties were performed. The most abundant sesquiterpene in the extracts was anthecotuloide, while the most present phenolics were caffeoyl quinic acid, quercetin, and kaempferol derivatives. UAE extract was the most efficient in the extraction of sesquiterpenoids and polyphenols. Considering the assays on antioxidant activity and enzyme inhibition, ASE extract showed highest phenolic content (62.92 mg gallic acid equivalent/g extract). Likewise, this extract showed highest radical scavenging (103.44 mg trolox equivalent [TE]/g extract and 155.70 mg TE/g extract, for DPPH and ABTS assays respectively)and reducing power potential (435.32 and 317.89 mg TE/g extract, for CUPRAC and FRAP assays, respectively). The different extracts showed similar results in the enzyme inhibition assays suggesting that the extraction methods used have no effect on observed enzyme activities. Novelty of our findings are the inhibitory action of the ethanol extract of A. cotula aerial parts on key enzymes associated with Alzheimer's disease (acetyl cholinesterase, butyryl cholinesterase), type 2 diabetes (α-amylase, α-glucosidase), and skin hyperpigmentation disorders (tyrosinase). Data collected from the present work further appraises the multiple potential biological properties of stinking chamomile suggesting the need for further investigation on its constituents.
Yazarlar (12)
1
Stefania Sut
2
Stefano Dall'Acqua
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Ismail Senkardes
5
Gizem Bulut
6
Aleksandra Cvetanović Kljakić
7
Alena Stupar
8
Anamarija Mandić
9
Carene Marie Nancy Picot-Allain
10
Ahmet Dogan
11
Kouadio Ibrahime Sinan
12
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
1 H-NMR
Anthecotuloide
Anthemis cotula
Antioxidant
Enzyme inhibitor
Sesquiterpenoids
Kurumlar
Institute of Food Technology in Novi Sad
Novi Sad Serbia
Marmara Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Padova
Padua Italy
University of Mauritius
Reduit Mauritius
University of Novi Sad
Novi Sad Serbia
Metrikler
26
Atıf
12
Yazar
6
Anahtar Kelime