Scopus
Chemical profiling of Centaurea bornmuelleri Hausskn. aerial parts by HPLC-MS/MS and their pharmaceutical effects: From nature to novel perspectives
Journal of Pharmaceutical and Biomedical Analysis · Eylül 2019
Makale Bilgileri
DergiJournal of Pharmaceutical and Biomedical Analysis
Yayın TarihiEylül 2019
Cilt / Sayfa174 · 406-413
Scopus ID2-s2.0-85067232915
Özet
Ethnobotanical evidences substantiate the use of several Centaurea species to treat and/or manage several human ailments. In the present study, the phytochemical profile of the ethyl acetate, methanol, and aqueous extracts (prepared by infusion and decoction) of Centaurea bornmuelleri Hausskn. aerial parts was established. The enzyme inhibitory and antioxidant properties were also determined by in vitro bioassays. Methanol extract (38.58 mg gallic acid equivalent/g extract) and ethyl acetate extract (38.83 mg rutin equivalent/g extract) possessed the highest concentration of phenolics and flavonoids, respectively. Aqueous extract prepared following traditional infusion method showed potent DPPH (38.54 mg TE/g extract) and ABTS (57.75 mg TE/g extract) scavenging abilities. The methanol extract (101.46 mg TE/g extract) of C. bornmuelleri exhibited potent reducing activity in the CUPRAC assay while the aqueous extract obtained by infusion was more active in the FRAP assay (69.81 mg TE/g extract). Ethyl acetate extract of C. bornmuelleri inhibited both acetylcholinesterase (1.14 mg galantamine equivalent [GALAE]/g extract), butyrylcholinesterase (0.63 mg GALAE/g extract), tyrosinase (69.84 mg kojic acid equivalent/g extract), amylase (19.90 mg acarbose equivalent [ACAE]/g extract), and glucosidase (33.12 mg ACAE/g extract). The phytochemical profile of C. bornmuelleri has been characterized and the main components quantified in order to provide scientific base to design innovative products including pharmaceuticals, cosmetics or nutraceuticals although further investigation concerning the isolation of the main bioactive compounds would be required.
Yazarlar (6)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
E. J. Llorent-Martínez
3
Kouadio Ibrahime Sinan
4
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
5
Carene Marie Nancy Picot-Allain
6
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Butyrylcholinesterase
Decoction
Infusion
Medicinal plants
Phytopharmaceuticals
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Jaén
Jaen Spain
University of Mauritius
Reduit Mauritius
Metrikler
16
Atıf
6
Yazar
5
Anahtar Kelime