Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Chemical profiling and pharmaco-toxicological activity of Origanum sipyleum extracts: Exploring for novel sources for potential therapeutic agents
Journal of Food Biochemistry · Kasım 2019
YÖKSİS Kayıtları
Chemical profiling and pharmaco‐toxicological activity of Origanum sipyleum extracts: Exploring for novel sources for potential therapeutic agents/title
JOURNAL OF FOOD BIOCHEMISTRY · 2019 SCI-Expanded
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Chemical profiling and pharmaco‐toxicological activity of Origanum sipyleum extracts: Exploring for novel sources for potential therapeutic agents/title
JOURNAL OF FOOD BIOCHEMISTRY · 2019 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiJournal of Food Biochemistry
Yayın TarihiKasım 2019
Cilt / Sayfa43
Scopus ID2-s2.0-85070531717
Erişim🔓 Açık Erişim
Özet
The phytochemical, antiradical, and enzyme inhibition profile of three solvent extracts (ethyl acetate, methanol, water) of Origanum sipyleum were assessed. We also performed a pharmacological study in order to explore protective effects induced by extracts in inflamed colon. LC-MS analysis revealed that the extracts contained different classes of phenolics. The aqueous extract showed the highest antioxidant and acetylcholinesterase (AChE) inhibitory effects. Total phenol and flavonoid contents were highest in aqueous and ethyl acetate extract, respectively. All extracts were effective in reducing colon pro-oxidant and pro-inflammatory biomarkers. The extracts revealed also able to inhibit fungal and bacterial species involved in ulcerative colitis, including Candida albicans, Candida tropicalis, Staphylococcus aureus, and Staphylococcus thyphimurium. Finally, we also showed the antiproliferative effects exerted by the EA extracts on human colon cancer HCT116 cell line. Concluding, our results indicated that O. sipyleum extracts displayed promising therapeutic properties which warrants further validation. Practical applications: The present phytochemical and biological studies, including antioxidant, anti-inflammatory, and antimicrobic assessments, showed significant protective effects exerted by O. sipyleum extracts in an experimental model of ulcerative colitis. The results are intriguing and suggest potential applications O. sipyleum extracts as sources of natural agents for the management of clinical symptoms related to ulcerative colitis, characterized by increased burden of oxidative stress and microbiome dysbiosis.
Yazarlar (17)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Claudio Ferrante
3
Giustino Orlando
4
Dimitrina Zheleva-Dimitrova
ORCID: 0000-0002-1952-9903
5
Reneta Gevrenova
ORCID: 0000-0002-1254-2419
6
Lucia Recinella
7
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
8
Sheila Leone
9
Luigi Brunetti
10
Muhammad Zakariyyah Aumeeruddy
11
Abdurrahman Aktumsek
12
Mohamad Fawzi Mahomoodally
13
Paola Angelini
ORCID: 0000-0002-6862-1079
14
Stefano Covino
15
Roberto Venanzoni
ORCID: 0000-0002-7768-0468
16
Bruno Tirillini
ORCID: 0000-0001-7581-8614
17
Luigi Menghini
ORCID: 0000-0002-7346-7395
Anahtar Kelimeler
antibacterial-antifungal
anti-inflammatory
enzyme inhibition
free radicals
Origanum sipyleum
phenolic compounds
Kurumlar
Medical University of Sofia
Sofia Bulgaria
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Perugia
Perugia Italy
Università degli Studi di Urbino Carlo Bo
Urbino Italy
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Metrikler
21
Atıf
17
Yazar
6
Anahtar Kelime