Scopus
Comprehensive approaches on the chemical constituents and pharmacological properties of flowers and leaves of American basil (Ocimum americanum L)
Food Research International · Kasım 2019
Makale Bilgileri
DergiFood Research International
Yayın TarihiKasım 2019
Cilt / Sayfa125
Scopus ID2-s2.0-85070826726
Özet
Ocimum americanum L. (Lamiaceae) is a common food condiment and also used in traditional medicine in the management of several human diseases. Nonetheless, there has been no effort to delineate the biological and phytochemical profiles of leaves and flowers prepared by different extractive solvents (ethyl acetate, methanol (MeOH), and water). The pharmacological potential of O. americanum extracts on pro-oxidant/pro-inflammatory mediators in rat colon specimens treated with lipopolysaccharide was investigated. In parallel, the inhibitory effects of the extracts on fungal and bacterial strains involved in ulcerative colitis were studied. Qualitative phytochemical analysis showed the presence of phenols, flavonoids, and tannins. Water extracts of flowers and leaves showed strong reducing and radicals scavenging potential. Both MeOH and ethyl acetate extracts of the leaves and flowers were able to inhibit acetylcholinesterase, butyrylcholinesterase, and tyrosinase. All the extracts inhibited the selected bacterial and fungal strains, while only ethyl acetate flower extract displayed antioxidant/anti-inflammatory effects in rat colon. The water and MeOH extracts stimulated colon lactate dehydrogenase (LDH) and serotonin (5-HT) and induced spontaneous migration of HCT116 cells. Future investigations should focus on the biological activity of isolated phytochemicals from the leaves and flowers of O. americanum, in order to clarify the mechanism(s) of action substantiating the observed pharmacological properties.
Yazarlar (19)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Claudio Ferrante
3
Diane Estelle Gnapi
4
Kouadio Ibrahime Sinan
5
Giustino Orlando
6
Lucia Recinella
7
Alina Diuzheva
ORCID: 0000-0003-2090-1634
8
József Jekő
9
Zoltán Cziáky
10
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
11
Sheila Leone
12
Luigi Brunetti
13
Carene Marie Nancy Picot-Allain
14
Mohamad Fawzi Mahomoodally
15
Paola Angelini
ORCID: 0000-0002-6862-1079
16
Stefano Covino
17
Roberto Venanzoni
ORCID: 0000-0002-7768-0468
18
Bruno Tirillini
ORCID: 0000-0001-7581-8614
19
Luigi Menghini
ORCID: 0000-0002-7346-7395
Anahtar Kelimeler
Anti-inflammatory
Free radicals
Lactate dehydrogenase
Phenolic
Serotonin
Kurumlar
Pavol Jozef Šafárik University in Košice
Kosice Slovakia
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Perugia
Perugia Italy
Università degli Studi di Urbino Carlo Bo
Urbino Italy
Université de Cocody-Abidjan
Abidjan Cote d'Ivoire
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
University of Nyíregyháza
Nyíregyháza Hungary
Metrikler
31
Atıf
19
Yazar
5
Anahtar Kelime