Scopus
YÖKSİS Eşleşti
Metabolomics-based profiling with chemometric approach to delineate the bio-pharmaceutical properties of fruit extracts from Ligustrum vulgare L
Industrial Crops and Products · Kasım 2019
YÖKSİS Kayıtları
Metabolomics-based profiling with chemometric approach to delineate the bio-pharmaceutical properties of fruit extracts from Ligustrum vulgare L
Industrial Crops and Products · 2019 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiIndustrial Crops and Products
Yayın TarihiKasım 2019
Cilt / Sayfa140
Scopus ID2-s2.0-85070082387
Özet
Ligustrum vulgare L. (Family: Oleaceae) is an evergreen shrub native to North-west Africa, Europe and Western Asia. In the present work, infusion (water), ethyl acetate, methanol and n-hexane extracts of the fruits of L. vulgare L. were studied for their in vitro antioxidant and enzyme inhibitory properties along with their untargeted polyphenolic profile (using an ultra-high-performance liquid chromatography-quadrupole time-of-flight (UHPLC-QTOF) mass spectrometry approach). Untargeted metabolomics coupled to multivariate statistics showed that Ligustrum fruit extracts were very abundant in polyphenols, such as flavonoids, tyrosols and lignans, with ethyl acetate allowing the highest recovery among the extraction solvents tested. The methanolic extract inhibited the highest acetylcholinesterase (AChE), tyrosinase and glucosidase activity (4.23 mg galatamine equivalent (GALAE)/g, 132.85 mg kojic acid equivalent (KAE)/g and 1.94 mmol acarbose equivalent (ACAE)/g respectively) while the ethyl acetate extract inhibited the highest butyrylcholinesterase (BChE) and amylase activity (4.92 mg GALAE/g and 0.73 mmol ACAE/g, respectively). However, the infusion showed the weakest activity against all the enzymes studied. However, the extract showed highest antioxidant property in the antioxidant assays (except for phosphomolybdenum). The present paper is the first comprehensive report on L. vulgare fruits and thus our findings are of considerable interest to design new bioproducts for the pharmaceutical and cosmeceutical industry in the future.
Yazarlar (7)
1
Gabriele Rocchetti
2
Biancamaria Senizza
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Ismail Senkardes
5
Nabeelah Bibi Sadeer
ORCID: 0000-0002-0602-0059
6
Mohamad Fawzi Mahomoodally
7
Luigi Lucini
ORCID: 0000-0002-5133-9464
Anahtar Kelimeler
Antioxidant
Bioactive compounds
Enzyme inhibition
Ligustrum
Metabolomics
Multivariate statistics
Kurumlar
Marmara Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Università Cattolica del Sacro Cuore, Campus di Piacenza e Cremona
Piacenza Italy
University of Mauritius
Reduit Mauritius
Metrikler
10
Atıf
7
Yazar
6
Anahtar Kelime