Scopus
In-vitro and in-silico anticancer potential of taxoids from Taxus wallichiana Zucc
Biologia Futura · Aralık 2019
Makale Bilgileri
DergiBiologia Futura
Yayın TarihiAralık 2019
Cilt / Sayfa70 · 295-300
Scopus ID2-s2.0-85090032655
Özet
Introduction: Natural products derived from medicinal plants provide beneficial cancer chemotherapeutic drugs. Bioactive constituents from plants are explored for their anticancer properties. Methods: Three known compounds (deacetylbaccatin III, tasumatrol B, and taxawallin J) were isolated from Taxus wallichiana. Compounds were screened against four cancer cell lines, such as eA498, HepG2, NCI-H226, and MDR 2780AD. Cytotoxic activity was evaluated using MTT assay against cancer cell lines. Results: Tasumatrol B showed good cytotoxic activity conducted for the improvement of inhibiting potential of these compounds against the cancer drug target protein (EGFR tyrosine kinase enzyme). The docking study showed that all compounds have binding affinities and interaction profile with the receptor tyrosine kinase. Discussion: The study suggests that these compounds could be used for the discovery of novel inhibitors against the target receptors for the treatment of cancer.
Yazarlar (13)
1
Mughal Qayum
2
Muhammad Nisar
3
Abdur Rauf
ORCID: 0000-0003-2429-5491
4
Imran Khan
5
Waqar Ahmad Kaleem
6
Muslim Raza
7
Nasiara Karim
8
Munawar Ahmad Saleem
9
Saud Bawazeer
10
Sengul Uysal
11
Gokhan Zengin
ORCID: 0000-0001-6548-7823
12
Saqib Jahan
13
Mohamed Fawzy Ramadan
Anahtar Kelimeler
cytotoxic activity
docking
phytochemicals
tyrosine kinase enzyme
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Faculty of Agriculture
Zagazig Egypt
Kohat University of Science and Technology (KUST)
Kohat Pakistan
Selçuk Üniversitesi
Selçuklu Turkey
Shenzhen Institute of Advanced Technology
Shenzhen China
Umm Al-Qura University
Makkah Saudi Arabia
University of Malakand
Chakdara Pakistan
University of Peshawar
Peshawar Pakistan
University of Swabi
Swabi Pakistan
Metrikler
4
Atıf
13
Yazar
4
Anahtar Kelime