Scopus
🔓 Açık Erişim
Phytochemical fingerprinting and in vitro bioassays of the ethnomedicinal fern tectaria coadunata (J. Smith) C. Christensen from Central Nepal
Molecules · Aralık 2019
Makale Bilgileri
DergiMolecules
Yayın TarihiAralık 2019
Cilt / Sayfa24
Scopus ID2-s2.0-85076345418
Erişim🔓 Açık Erişim
Özet
Tectaria coadunata, an ethnomedicinal fern used in Nepal to treat a large number of diseases, has been poorly studied with regard to its phytochemical composition and possible bioactivity. This study was performed with the aim of supporting traditional medicine as a new source of bioactive constituents. Phytochemical compositions of methanol extracts were determined by nuclear magnetic resonance (NMR), liquid chromatography-diode array detector-mass spectrophotometry (LC-DAD-MS), and liquid chromatography-fluorescence-mass spectrometry. Quali-quantitative data revealed large amount of procyanidins, mainly of the A-type, as well as eriodictyol-7-O-glucuronide and luteolin-7-O-glucoronide as main constituents. The antioxidant, cytotoxic, and inhibitory activity of five enzymes that are implicated in human diseases was evaluated for the extract and fractions. High free-radical scavenging activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays and inhibitory activities against cholinesterases and tyrosinase were observed. Furthermore, a moderate cytotoxic effect was observed on the 2008 and BxPC3 cell lines. Overall results showed potential usefulness of this fern as a source of phytochemicals for pharmaceutical uses.
Yazarlar (10)
1
Shyam Sharan Shrestha
2
Stefania Sut
3
Serena Barbon di Marco
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Valentina Gandin
6
Michele de Franco
7
Deepak Raj Pant
8
Mohamad Fawzi Mahomoodally
9
Stefano Dall'Acqua
10
Sangeeta Rajbhandary
Anahtar Kelimeler
Antioxidant
Chromatography
Flavonols
Medicinal fern
Procyanidins
Tectaria coadunata
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Tribhuvan University
Kathmandu Nepal
Università degli Studi di Padova
Padua Italy
University of Mauritius
Reduit Mauritius
Metrikler
10
Atıf
10
Yazar
6
Anahtar Kelime