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Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents

Food and Chemical Toxicology · Ocak 2020

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YÖKSİS Kayıtları
Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents
Food and Chemical Toxicology · 2020 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
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Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
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Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
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Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
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Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
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Evaluation of antioxidant potential, enzyme inhibition activity and phenolic profile of Lathyrus cicera and Lathyrus digitatus : Potential sources of bioactive compounds for the food industry
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UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation
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Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives
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Makale Bilgileri

Dergi Food and Chemical Toxicology
ISSN02786915
Yayın TarihiOcak 2020
Cilt / Sayfa135
DOI10.1016/j.fct.2019.111052
Scopus ID2-s2.0-85076432662
Özet Ethnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of ‘mad honey’ poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. luteum extracts on A549 lung cancer cell line was evaluated using MTT cell viability assay. Besides, HPLC-ESI-MSn approach was employed to elucidate the secondary metabolite profiles of R. luteum in order to establish any structure-activity relationship. Methanol and water extracts of R. luteum possessed highest radical scavenging and reducing properties while the ethyl acetate extract showed highest metal chelating properties. In terms of enzyme inhibition, the methanol and ethyl acetate extracts of R. luteum, possessing epigallocatechin, were active inhibitors of cholinesterase enzymes, α-glucosidase, and tyrosinase. Water extract caused growth inhibition of A549 cells with 207.2 μg/ml IC50 value. Though R. luteum has received little scientific attention due to the occurrence of grayanotoxins in the plant, however, data presented in this work shows promising biological activity of R. luteum and highlighted its role as a potential source of antioxidant and key enzyme inhibitors.

Yazarlar (10)

1
Mohamad Fawzi Mahomoodally
2
Elwira Sieniawska
ORCID: 0000-0003-4773-0329
3
Kouadio Ibrahime Sinan
4
Marie Carene Nancy Picot-Allain
5
Serife Yerlikaya
6
Mehmet Cengiz Baloglu
7
Yasemin Celik Altunoglu
8
Ismail Senkardes
9
Kannan RR Rengasamy
10
Gokhan Zengin
ORCID: 0000-0001-6548-7823

Anahtar Kelimeler

Anticancer Enzyme inhibitory Honeysuckle azalea PCA analysis Yellow azalea

Kurumlar

Kastamonu University
Kastamonu Turkey
Konkuk University
Seoul South Korea
Marmara Üniversitesi
Istanbul Turkey
Medical University of Lublin
Lublin Poland
Selçuk Üniversitesi
Selçuklu Turkey
University of Florida Institute of Food and Agricultural Sciences
Gainesville United States
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Food and Chemical Toxicology
Q1
SJR Skoru0,750
H-Index223
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Food Science (Q1)
Medicine (miscellaneous) (Q2)
Toxicology (Q2)
Dergi sayfasına git

Metrikler

21
Atıf
10
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

GZ
GÖKHAN ZENGİN
Prof. Dr.

Hızlı Erişim

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