Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Multiple biological activities of two Onosma species (O. sericea and O. stenoloba) and HPLC-MS/MS characterization of their phytochemical composition
Industrial Crops and Products · Şubat 2020
YÖKSİS Kayıtları
Multiple biological activities of two Onosma species (O. sericea and O. stenoloba) and HPLC-MS/MS characterization of their phytochemical composition
Industrial Crops and Products · 2020 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer skin diseases and type II diabetes
2014 ISSN: 09266690 SCI-Expanded 4 atıf
Prof. Dr. GÖKHAN ZENGİN →
HPLC DAD analysis of phenolic compounds and antioxidant properties of Asphodeline lutea roots from Bulgaria and Turkey
2014 ISSN: 09266690 SCI-Expanded 1 atıf
Prof. Dr. GÖKHAN ZENGİN →
Phenolic constituent antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L from Turkey A phytochemical study
2015 ISSN: 09266690 SCI-Expanded 1 atıf
Prof. Dr. GÖKHAN ZENGİN →
Composition antioxidant antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies subsp vulgare and subsp hirtum essential oils
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Changes in the fatty acid compositions and bioactivities of clary sage seeds depending on harvest year
2012 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. ERAY TULUKCU →
A phytochemical study on Potentilla anatolica An endemic Turkish plant
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Phenolic constituent antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L from Turkey A phytochemical study
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Composition antioxidant antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies subsp vulgare and subsp hirtum essential oils
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
HPLC DAD analysis of phenolic compounds and antioxidant properties of Asphodeline lutea roots from Bulgaria and Turkey
2014 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer skin diseases and type II diabetes
2014 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Chemical and biological fingerprints of two Fabaceae species Cytisopsis dorycniifolia and Ebenus hirsuta Are they novel sources of natural agents for pharmaceutical and food formulations
2016 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
A study on in vitro enzyme inhibitory properties of Asphodeline anatolica New sources of natural inhibitors for public health problems
2016 ISSN: 09266690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response
2016 ISSN: 09266690 SCI
Prof. Dr. YÜKSEL KAN →
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
2018 ISSN: 09266690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
2018 ISSN: 0926-6690 SCI-Expanded Q1
Prof. Dr. GÖKHAN ZENGİN →
Bioactivity-guided isolation of cytotoxic secondary metabolites from the roots of Glycyrrhiza glabra and elucidation of their mechanisms of action
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. YÜKSEL KAN →
Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Exploring the therapeutic potential and phenolic composition of two Turkish ethnomedicinal plants – Ajuga orientalis L. and Arnebia densiflora (Nordm.) Ledeb.
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN09266690
Yayın TarihiŞubat 2020
Cilt / Sayfa144
Scopus ID2-s2.0-85076715055
Özet
Members of the Onosma genus are widely used in folk medicine and they have great interest in the pharmaceutical industry. In this study, phytochemical characterization, antioxidant activity (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), metal chelation, and phosphomolybdenum assays), enzyme inhibition (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-amylase, α-glucosidase, and tyrosinase), antimicrobial activity (microdilution method), genotoxic and antigenotoxic (by using Drosophila melanogaster larvae and Comet assay) potentials of Onosma sericea Willd. and Onosma stenoloba Hausskn. ex Riedl. were investigated. Additionally, the bioactive compounds were identified by high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) analysis. Generally, O. sericea showed stronger antioxidant activity, while O. stenoloba extract exhibited stronger enzyme inhibitory abilities (cholinesterases and α-amylase). The protective effects of extracts, at the concentration range from 25 to 400 μg/mL, against hydroxyl radical-induced DNA damage were dose-dependent, increasing with a higher dosage. The extracts at the highest concentration (80 mg/mL) showed the absence of genotoxicity in vivo. Antigenotoxic effects were evident after treatment with both extracts, with a percentage reduction of over 80 %. Overall antimicrobial activity of studied extracts was weak, with the lowest minimal inhibitory concentration values (MIC) of 2.5 mg/mL. Taken together, obtained results showed that tested Onosma species can be considered as promising sources of bioactive phytochemicals for pharmacological purposes.
Yazarlar (9)
1
Jelena S. Katanić Stanković
2
Ramazan Ceylan
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Sanja Matić
5
Tatjana Jurić
6
Alina Diuzheva
ORCID: 0000-0003-2090-1634
7
József Jekő
8
Zoltán Cziáky
9
Abdurrahman Aktumsek
Anahtar Kelimeler
Antigenotoxic
Enzyme inhibition
Flavonoids
Natural agents
Onosma
Kurumlar
Czech University of Life Sciences Prague
Prague Czech Republic
Selçuk Üniversitesi
Selçuklu Turkey
University of Kragujevac
Kragujevac Serbia
University of Nyíregyháza
Nyíregyháza Hungary
Univerzitet u Novom Sadu, Poljoprivredni fakultet
Novi Sad Serbia
Scimago Dergi (ISSN Eşleşmesi)
Industrial Crops and Products
Q1
SJR Skoru0,974
H-Index186
YayıncıElsevier B.V.
ÜlkeNetherlands
Agronomy and Crop Science (Q1)
Metrikler
30
Atıf
9
Yazar
5
Anahtar Kelime