Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Chemical characterization and bioactive properties of different extracts from fibigia clypeata, an unexplored plant food
Foods · Haziran 2020
YÖKSİS Kayıtları
Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food
Foods · 2020 SCI-Expanded
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Makale Bilgileri
DergiFoods
Yayın TarihiHaziran 2020
Cilt / Sayfa9
Scopus ID2-s2.0-85085709709
Erişim🔓 Açık Erişim
Özet
Fibigia clypeata (L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. The current investigation aimed at assessing the antioxidant potential and inhibitory activity of ethyl acetate, methanol, and aqueous extracts of F. clypeata against key enzymes targeted in the management of type II diabetes (α-amylase and α- glucosidase), Alzheimer's disease (acetylcholinesterase and butyrylcholinesterase), and skin hyperpigmentation (tyrosinase). Cytotoxicity of the extracts was also determined using normal VERO and cancer FaDu and SCC-25 cell lines. Besides, LC-MS was employed to investigate the detailed phytochemical profiles of the extracts. The methanol extract showed potent enzyme inhibitory activity (4.87 mg galantamine equivalent/g, 3.52 mg galantamine equivalent/g, 126.80 mg kojic acid equivalent/g, and 24.68 mg acarbose equivalent/g, for acetylcholinesterase, butyrylcholinesterase, tyrosinase, and α-glucosidase, respectively) and antioxidant potential (96.52, 109.10, 154.02, and 104.85 mg trolox equivalent/g, for DPPH, ABTS, CUPRAC, and FRAP assays, respectively). Interestingly, caffeic acid-O-hexoside derivative, caffeyl alcohol O-glucopyranoside, and ferulic acid derivative were identified in all extracts. F. clypeata extracts showed no cytotoxicity towards VERO cell line and a weak cytotoxic potential against FaDu and SCC-25 cell lines. Interesting scientific evidence gathered from the present study support further investigation on F. clypeata in the view of designing and developing a novel therapeutic agent for the management of Alzheimer's disease, type II diabetes, skin hyperpigmentation problems, as well as cancer.
Yazarlar (12)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Mohamad Fawzi Mahomoodally
3
Gabriele Rocchetti
4
Luigi Lucini
ORCID: 0000-0002-5133-9464
5
Elwira Sieniawska
ORCID: 0000-0003-4773-0329
6
Łukasz Świątek
ORCID: 0000-0003-1626-680X
7
Barbara Rajtar
ORCID: 0000-0002-8857-8688
8
Małgorzata Polz-Dacewicz
ORCID: 0000-0002-3222-184X
9
Ismail Senkardes
10
Abdurrahman Aktumsek
11
Carene Marie Nancy Picot-Allain
12
Domenico Montesano
ORCID: 0000-0002-8857-2091
Anahtar Kelimeler
Antioxidants
Cytotoxicity
Enzyme inhibition
Fibigia clypeata
Mass spectrometry
Kurumlar
Duy Tan University
Da Nang Viet Nam
Marmara Üniversitesi
Istanbul Turkey
Medical University of Lublin
Lublin Poland
Selçuk Üniversitesi
Selçuklu Turkey
Università Cattolica del Sacro Cuore, Campus di Piacenza e Cremona
Piacenza Italy
Università degli Studi di Perugia
Perugia Italy
University of Mauritius
Reduit Mauritius
Metrikler
9
Atıf
12
Yazar
5
Anahtar Kelime