Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
In vitro and in silico approach to determine neuroprotective properties of iridoid glycosides from aerial parts of Scrophularia amplexicaulis by investigating their cholinesterase inhibition and anti-oxidant activities
Biointerface Research in Applied Chemistry · Haziran 2020
YÖKSİS Kayıtları
In vitro and in silico approach to determine neuroprotective properties of iridoid glycosides from aerial parts of Scrophularia amplexicaulis by investigating their cholinesterase inhibition and anti-oxidant activities
Biointerface Research in Applied Chemistry · 2020 emergency citation index
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Makale Bilgileri
DergiBiointerface Research in Applied Chemistry
Yayın TarihiHaziran 2020
Cilt / Sayfa10 · 5429-5454
Scopus ID2-s2.0-85085574569
Erişim🔓 Açık Erişim
Özet
Three iridoid glycosides included 6-O-methyl, 1-glucopyranosyl catalpol (Compound 1), 6-O-α-L (3"-O-trans, 4"-O-trans cinnamoyl)-rhamnopyranosyl catalpol (Compound 2) and scropolioside D (Compound 3) were isolated from aerial parts of S. amplexicaulis using chromatographic methods. The structures were determined by different spectroscopic data. The inhibitory effects (IC50 values) of the compounds on cholinesterase (AChE and BChE) was determined by in-vitro assays. Docking studied were performed to investigate receptor-ligands interactions. The antioxidant capacity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 2, 2'-azino-bis[3-ethylbenzothiazoline]-6-sulphonic acid (ABTS) radical cation, cupric ion reducing activity (CUPRAC), ferric reducing antioxidant power (FRAP), phosphomolybdenum and metal chelating assays. AChE and BChE were moderately inhibited by all of the investigated iridoid glycosides (compared to galantamine). Compound 2 and compound 3 showed comparable anti-oxidant effects with the Trolox as the control in phosphomolybdenum assay. Also, compound 1, showed acceptable activities in ABTS radical scavenging and Phosphomolybdenum assays compared to the control.
Yazarlar (5)
1
Azadeh Hamedi
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Abdurrahman Aktumsek
4
Zeliha Selamoglu
5
Ardalan Pasdaran
Anahtar Kelimeler
Acetylcholinesterase
Alzheimer’s disease
Anti-oxidant
Butyrylcholinesterase
Iridoid glycosides
Neuroprotective
Kurumlar
Medicinal Plant Processing Research Center SUMS
Meymand Iran
Niğde Ömer Halisdemir University
Nigde Turkey
School of Pharmacy
Shiraz Iran
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
19
Atıf
5
Yazar
6
Anahtar Kelime