Scopus
🔓 Açık Erişim
Chemical profile, antiproliferative, antioxidant and enzyme inhibition activities of Ocimum basilicum L. and Pulicaria undulata (L.) C.A. Mey. grown in Sudan
South African Journal of Botany · Ağustos 2020
Makale Bilgileri
DergiSouth African Journal of Botany
Yayın TarihiAğustos 2020
Cilt / Sayfa132 · 403-409
Scopus ID2-s2.0-85086660181
Erişim🔓 Açık Erişim
Özet
In the present study, essential oils extracted from the leafy stems of Ocimum basilicum (Family Lamiaceae) and Pulicaria undulata (Family Asteraceae) were investigated for their chemical profiles and biological activity including antioxidant, antiproliferative and enzyme inhibition activities. The chemical composition of essential oil was determined using Gas Chromatography-Mass Spectrometry. The antioxidant capacity was tested by scavenging of free radicals, reduction potential, chelating ability on ferrous ions and phosphomolybdenum assays. Cell viability was evaluated on human breast carcinoma (MCF7) and human colon adenocarcinoma (HT29 and HCT116) cell lines. Enzymatic activity was evaluated against α-glucosidase, α-amylase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Based on the results obtained, in silico studies was performed to identify potential inhibitor of tyrosinase activity. Results showed that oil of O. basilicum was predominantly composed of methyl chavicol (51.9%) followed by linalool (20.0%). Oil of P. undulata was represented by oxygenated monoterpenes (96.9%) with carvotanacetone (92.1%) as the main molecule. Both oils exerted antioxidant activities with oil from P. undulata exerted significant (p<0.05) higher scavenging activity (20.92±0.05DPPH and 62.36±0.25ABTS mg trolox equivalents (TEs)/g) while that obtained from O. basillicum showed significant (p<0.05) higher total antioxidant activity (16.72±0.95 mmol TEs/g), ion reducing power (86.30±2.80FRAP and 115.31±2.03CUPRAC mg TEs/g) and metal chelating ability (21.08±3.45 mg disodium edetate equivalents /g). Both oils showed considerable tyrosinase and α-amylase inhibition activity while only oil of P. undulata displayed acetylcholinesterase (0.95 ± 0.06 mg galanthamine equivalents (GALAEs)/g), butyrylcholinesterase (1.19 ± 0.13 mg GALAEs/g) and α-glucosidase (32.59 ± 0.20 mg acarbose equivalents (ACAEs)/g) inhibition capacity. Both oils showed good anti-proliferative activity towards the three cell lines with higher activity observed from that of O. basillicum (2.8–3.3 µg/mL). In silico studies suggested that methyl chavicol represent a potential inhibitor of tyrosinase activity. In conclusion, the two oils show promise as natural agents with functional properties for food, cosmetics, and pharmaceutical industries.
Yazarlar (10)
1
Atif B.A. Mohammed
2
Sakina Yagi
3
Tzvetomira Tzanova
4
Hervé Schohn
5
Haider Abdelgadir
6
Azzurra Stefanucci
7
Adriano Mollica
8
Mohamad Fawzi Mahomoodally
9
Talal A. Adlan
10
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
Antioxidant
Antiproliferative
Chemical profile
Enzyme inhibition
In silico study
Ocimum basilicum
Pulicaria undulata
Kurumlar
Al Baha University
Al Aqiq Saudi Arabia
CRAN Centre de Recherche en Automatique de Nancy
Vandoeouvre-les-Nancy France
Duy Tan University
Da Nang Viet Nam
Khartoum University
Khartoum Sudan
Selçuk Üniversitesi
Selçuklu Turkey
Université de Lorraine
Nancy France
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Ibn Sina
West Bank, Khartoum Sudan
University of Mauritius
Reduit Mauritius
University of Shendi
Shendi Sudan
Metrikler
48
Atıf
10
Yazar
7
Anahtar Kelime