Scopus
🔓 Açık Erişim
Chemical profiling and discrimination of essential oils from six ferula species using gc analyses coupled with chemometrics and evaluation of their antioxidant and enzyme inhibitory potential
Antibiotics · Ağustos 2020
Makale Bilgileri
DergiAntibiotics
Yayın TarihiAğustos 2020
Cilt / Sayfa9 · 1-12
Scopus ID2-s2.0-85089674216
Erişim🔓 Açık Erişim
Özet
The differences in the composition of essential oils obtained from the aerial parts of six Ferula species viz., F. caratavica (Fc), F. kuchistanica (Fk), F. pseudoreoselinum (Fp), F. samarcandica (Fs), F. tenuisecta (Ft) and F. varia (Fv) were detected both qualitatively and quantitatively using GC-MS and GC-FID analyses. One hundred and six metabolites were identified that account for 92.1, 96.43, 87.43, 95.95, 92.90 and 89.48% of Fc, Fk, Fp, Fs, Ft and Fv whole essential oils, respectively. The data from the GC-MS analyses were subjected to unsupervised pattern recognition chemometric analysis utilizing principal component analysis (PCA) to improve the visualization of such differences among the six species. Fk and Ft are very closely related to each other and were gathered together in one cluster. The antioxidant potential was assessed in vitro using different assays including 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), cupric reducing antioxidant capacity (CUPRAC), ferric reducing power (FRAP) and phosphomolybdenum (PM) assays. Ft and Fp exhibited the most notable antioxidant properties as evidenced by their pronounced activities in most of the antioxidant assays performed, followed by Fc. Fk showed the most effective tyrosinase inhibitory potential, which was estimated as 119.67 mgKAE/g oil, while Fp exhibited the most potent α-amylase inhibitory potential, which was equivalent to 2.61 mmol ACAE/g oil. Thus, it was concluded that Ferula species could serve as a promising natural antioxidant drug that could be included in different products and spices to alleviate hyperglycemia and used as a natural ingredient in pharmaceutical cosmetics to counteract hyperpigmentation.
Yazarlar (7)
1
Fadia S. Youssef
2
Munira A. Mamatkhanova
3
Nilufar Z. Mamadalieva
ORCID: 0000-0003-1756-3638
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Salima F. Aripova
6
Elham Alshammari
7
Mohamed L. Ashour
ORCID: 0000-0002-9270-6267
Anahtar Kelimeler
Antioxidant activity
Chemometrics
Enzyme inhibition
Essential oils
Ferula
GC
Kurumlar
Academy of Sciences of the Republic of Uzbekistan
Tashkent Uzbekistan
Faculty of Pharmacy - Ain Shams University
Cairo Egypt
Leibniz Institut fur Pflanzenbiochemie
Halle Germany
Princess Nourah Bint Abdulrahman University
Riyadh Saudi Arabia
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
17
Atıf
7
Yazar
6
Anahtar Kelime