Scopus
🔓 Açık Erişim
Distinctive evidence involved in the role of endocannabinoid signalling in parkinson’s disease: A perspective on associated therapeutic interventions
International Journal of Molecular Sciences · Eylül 2020
Makale Bilgileri
DergiInternational Journal of Molecular Sciences
Yayın TarihiEylül 2020
Cilt / Sayfa21 · 1-28
Scopus ID2-s2.0-85090181942
Erişim🔓 Açık Erişim
Özet
Current pharmacotherapy of Parkinson’s disease (PD) is symptomatic and palliative, with levodopa/carbidopa therapy remaining the prime treatment, and nevertheless, being unable to modulate the progression of the neurodegeneration. No available treatment for PD can enhance the patient’s life-quality by regressing this diseased state. Various studies have encouraged the enrichment of treatment possibilities by discovering the association of the effects of the endocannabinoid system (ECS) in PD. These reviews delineate the reported evidence from the literature on the neuromodulatory role of the endocannabinoid system and expression of cannabinoid receptors in symptomatology, cause, and treatment of PD progression, wherein cannabinoid (CB) signalling experiences alterations of biphasic pattern during PD progression. Published papers to date were searched via MEDLINE, PubMed, etc., using specific key words in the topic of our manuscript. Endocannabinoids regulate the basal ganglia neuronal circuit pathways, synaptic plasticity, and motor functions via communication with dopaminergic, glutamatergic, and GABAergic signalling systems bidirectionally in PD. Further, gripping preclinical and clinical studies demonstrate the context regarding the cannabinoid compounds, which is supported by various evidence (neuroprotection, suppression of excitotoxicity, oxidative stress, glial activation, and additional benefits) provided by cannabinoid-like compounds (much research addresses the direct regulation of cannabinoids with dopamine transmission and other signalling pathways in PD). More data related to endocannabinoids efficacy, safety, and pharmacokinetic profiles need to be explored, providing better insights into their potential to ameliorate or even regress PD.
Yazarlar (10)
1
Tapan Behl
2
Gagandeep Kaur
3
Simona Bungau
4
Rishabh Jhanji
5
Arun Kumar
6
Vineet Mehta
7
Gokhan Zengin
ORCID: 0000-0001-6548-7823
8
Roxana Brata
9
Syed Shams Ul Hassan
10
Ovidiu Fratila
Anahtar Kelimeler
Cannabinoid 1 receptor
Cannabinoid 2 receptor
Endocannabinoids
Endocannabinoid system
Neuroprotection
Parkinson’s disease
Kurumlar
Chitkara University, Punjab
Rajpura India
Government College of Pharmacy
Rohru India
National Agri-Food Biotechnology Institute
Mohali India
Selçuk Üniversitesi
Selçuklu Turkey
Shanghai Jiao Tong University
Shanghai China
Universitatea din Oradea, Facultatea de Medicina
Oradea Romania
Metrikler
25
Atıf
10
Yazar
6
Anahtar Kelime