Scopus
🔓 Açık Erişim
Pharmacological properties and chemical profiles of Passiflora foetida L. Extracts: Novel insights for pharmaceuticals and nutraceuticals
Processes · Eylül 2020
Makale Bilgileri
DergiProcesses
Yayın TarihiEylül 2020
Cilt / Sayfa8
Scopus ID2-s2.0-85090499248
Erişim🔓 Açık Erişim
Özet
In the present study, Passiflora foetida extracts characterized by different polarities were studied for their phytochemical profile, enzyme inhibitory, and antioxidant potentials. In silico, in vitro and ex vivo studies were also carried out on methanol and water extracts for predicting pharmacokinetics and pharmacodynamics. In this regard, neuronal HypoE22 cells, isolated mouse skin tissues, and pathogen dermatophytes strains were exposed to extracts. Emphasis was given to the preventing effects induced by the extracts on hydrogen peroxide-induced alterations of prostaglandin E2 (PGE2), l-dopa, and serotonin. Chemical analysis revealed the presence of similar compounds in infusion and methanolic extracts. The ex vivo studies also showed protective skin properties by P. foetida water and methanol extracts, as evidenced by the decrease of hydrogen peroxide-induced PGE2 level. Additionally, the blunting effects on hydrogen peroxide-induced l-dopa levels are consistent with the anti-tyrosinase effect exerted by both extracts. In silico studies demonstrated the affinity of extracts' phytochemicals, namely apigenin, chrysoeriol, loliolide, luteolin, quercetin, and vitexin, towards cyclo-oxygenase-2 and tyrosinase. Finally, microbiological tests demonstrated the efficacy of P. foetida methanol and water extracts as anti-mycotic agents against Trichophyton and Arthroderma species, involved in skin inflammation. Hence, P. foetida L. extracts could represent potential sources of pharmaceuticals and nutraceuticals.
Yazarlar (20)
1
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
2
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
3
Kouadio Ibrahime Sinan
4
Maria Chiara Ciferri
5
Giancarlo Angeles Flores
ORCID: 0000-0001-6651-9794
6
Gokhan Zengin
ORCID: 0000-0001-6548-7823
7
Ouattara Katinan Etienne
8
Gunes Ak
9
Mohamad Fawzi Mahomoodally
10
Sharmeen Jugreet
11
Zoltán Cziáky
12
József Jekő
13
Lucia Recinella
14
Luigi Brunetti
15
Sheila Leone
16
Paola Angelini
ORCID: 0000-0002-6862-1079
17
Roberto Venanzoni
ORCID: 0000-0002-7768-0468
18
Luigi Menghini
ORCID: 0000-0002-7346-7395
19
Claudio Ferrante
20
Giustino Orlando
Anahtar Kelimeler
Anti-oxidant/anti-inflammatory effects
Bioinformatics/network pharmacology
Chemical profile
Neuroprotection
Passiflora foetida
Skin protection
Kurumlar
Duy Tan University
Da Nang Viet Nam
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Perugia
Perugia Italy
Université de Cocody-Abidjan
Abidjan Cote d'Ivoire
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
University of Nyíregyháza
Nyíregyháza Hungary
Metrikler
13
Atıf
20
Yazar
6
Anahtar Kelime