Scopus
🔓 Açık Erişim
Antimicrobial, antioxidant, and antiproliferative effects of coronilla minima: An unexplored botanical species
Antibiotics · Eylül 2020
Makale Bilgileri
DergiAntibiotics
Yayın TarihiEylül 2020
Cilt / Sayfa9 · 1-15
Scopus ID2-s2.0-85091092917
Erişim🔓 Açık Erişim
Özet
Coronilla species, belonging to the Coronilla genus (Fabaceae), have long been used in traditional medicine for treating cold, diabetes, pain, and as cardiotonics. The goal of the present study was to explore the phytochemical composition and pharmaco-toxicological properties of C. minima. In this regard, phenolic content, scavenging/reducing properties and antimicrobial activity toward pathogen bacterial (Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus) and fungal strains (Candida albicans, C. tropicalis, Aspergillus tubigensis and A. minutus) were investigated. Extract effects on human colon cancer HCT116 cell viability were also assayed. Finally, a bioinformatics approach was conducted with the aim to identify putative microbial and human protein targets underlying antibacterial, antimycotic, and antiproliferative effects. Phytochemical investigation suggested that water extract is richer in terms of total flavonoid and phenol content, whereas the hydroalcoholic extract was revealed to be more potent as antioxidant agent. According to bioinformatics analysis, the antibacterial activity of the hydroalcoholic extract could be related to its content in resveratrol. The presence of resveratrol could also explain the hydroalcoholic extract efficacy in reducing HCT116 cell viability. In conclusion, the present study represents the first phytochemical and bio-pharmacological investigation about C. minima. Like other plants belonging to the Fabaceae family, C. minima revealed a good source of resveratrol, which could explain, albeit partially, the efficacy of the hydroalcoholic extract as antimicrobial, antioxidant, and antiproliferative agent.
Yazarlar (15)
1
Claudio Ferrante
2
Paola Angelini
ORCID: 0000-0002-6862-1079
3
Roberto Venanzoni
ORCID: 0000-0002-7768-0468
4
Giancarlo Angeles Flores
ORCID: 0000-0001-6651-9794
5
Bruno Tirillini
ORCID: 0000-0001-7581-8614
6
Lucia Recinella
7
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
8
Luigi Brunetti
9
Sheila Leone
10
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
11
Maria Chiara Ciferri
12
Gokhan Zengin
ORCID: 0000-0001-6548-7823
13
Gunes Ak
14
Luigi Menghini
ORCID: 0000-0002-7346-7395
15
Giustino Orlando
Anahtar Kelimeler
Antibacterial effects
Antioxidant effects
Antiproliferative effects
Bioinformatics/docking
Coronilla minima
Resveratrol
Unexplored botanical species
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Perugia
Perugia Italy
Università degli Studi di Urbino Carlo Bo
Urbino Italy
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
15
Atıf
15
Yazar
7
Anahtar Kelime