Scopus
Exploring the therapeutic promise of targeting HMGB1 in rheumatoid arthritis
Life Sciences · Ekim 2020
Makale Bilgileri
DergiLife Sciences
Yayın TarihiEkim 2020
Cilt / Sayfa258
Scopus ID2-s2.0-85089245804
Özet
High mobility group box-1 (HMGB1) protein is a diverse, single polypeptide moiety, present in mammalian eukaryotic cells. In response to stimuli, this nuclear protein is actively secreted in to the extracellular compartment or passively released by the necrotic cells, in order to mediate inflammatory responses, by forming complexes with IL-1α, IL-1β, LPS and other moieties, and binding to RAGE, TLR and other receptor ligands, initiating downstream, signaling processes. This molecule acts as a proinflammatory cytokine and contributes to the progression of diseases like, acute lung injury, autoimmune liver damage, graft rejection immune response and arthritis. Small concentrations of HMGB1 are released during apoptosis, which facilitates oxidative regulation on Cys106, and propagates immune inactivating tolerogenic signals in the body. The review portrays the role of HMGB1 in rheumatoid arthritis, evidently supported by pre-clinical and clinical investigations, demonstrating extensive HMGB1 expression in synovial tissue and fluid as well as serum, excessive expression of transduction receptor signaling molecules, bone remodeling and uncontrolled expression of bone destroying osteoclastogenesis, resulting in destruction of articular cartilage, bone deformation and synovial proliferation, alleviating the pathogenesis in RA disease. Moreover, the review highlights the therapeutic regime targeting HMGB1, facilitating inhibition of its actions and release into the extracellular compartment, to ameliorate the destructive events that prevail in rheumatoid arthritis.
Yazarlar (10)
1
Ishnoor Kaur
2
Tapan Behl
3
Simona Bungau
4
Arun Kumar
5
Vineet Mehta
6
Dhruv Setia
7
Md Sahab Uddin
8
Gokhan Zengin
ORCID: 0000-0001-6548-7823
9
Lotfi Aleya
10
Sandeep Arora
Anahtar Kelimeler
Apoptosis
HMGB1
Necrotic cells
Receptor ligands
Rheumatoid arthritis
Kurumlar
Chitkara University, Punjab
Rajpura India
Government College of Pharmacy
Shimla India
Pharmakon Neuroscience Research Network
Dhaka Bangladesh
Southeast University, Dhaka
Dhaka Bangladesh
Universitatea din Oradea, Facultatea de Medicina
Oradea Romania
Université Bourgogne Franche-Comté
Besancon France
University Campus
Konya Turkey
Metrikler
38
Atıf
10
Yazar
5
Anahtar Kelime