Scopus
🔓 Açık Erişim
Pleotropic Effects of Polyphenols in Cardiovascular System
Biomedicine and Pharmacotherapy · Ekim 2020
Makale Bilgileri
DergiBiomedicine and Pharmacotherapy
Yayın TarihiEkim 2020
Cilt / Sayfa130
Scopus ID2-s2.0-85091571301
Erişim🔓 Açık Erişim
Özet
Numerous epidemiological and clinical studies demonstrate the beneficial effects of naturally occurring, polyphenol supplementations, on cardiovascular system. The present review emphasizes on the risk factors associated with cardiovascular disorders (involving heart and blood vessels), and overview of preclinical and clinical trials on polyphenols for the treatment of cardiovascular diseases. The review collaborates PUBMED, Google Scholar and Research gate databases, which were explored using keywords and their combinations such as polyphenols, cardiovascular disease, flavonoids, atherosclerosis, cardiovascular risk factors and several others, to create an eclectic manuscript. The potency and efficacy of these polyphenols are mainly depending upon the amount of consumption and bioavailability. Recent data showed that polyphenols also exert beneficial actions on vascular system by blocking platelet aggregation and oxidation of low-density lipoprotein (LDL), ameliorating endothelial dysfunction, reducing blood pressure, improving antioxidant defenses and alleviating inflammatory responses. Several studies evidently support the cardioprotective actions mediated by polyphenols, however, some studies or long-term follow-up of human studies, did not demonstrate decisive outcomes because of variations in dose regimen and lack of appropriate controls. Therefore, more data is required to explore the therapeutic benefits of bioactive compounds as a preventive therapy for CVDs.
Yazarlar (12)
1
Tapan Behl
2
Simona Bungau
3
Keshav Kumar
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Fazlullah Khan
6
Arun Kumar
7
Rajwinder Kaur
8
Thangaval Venkatachalam
9
Delia Mirela Tit
10
Cosmin Mihai Vesa
11
Ghita Barsan
12
Danut Eugeniu Mosteanu
Anahtar Kelimeler
Antioxidant defenses
Cardiovascular disease
Hyperlipidemia
Platelet aggregation
Polyphenol
Kurumlar
Chitkara University, Punjab
Rajpura India
JKKMMRF College of Pharmacy
Namakkal India
“Nicolae Bălcescu” Land Forces Academy
Sibiu Romania
Selçuk Üniversitesi
Selçuklu Turkey
The Institute of Pharmaceutical Sciences (TIPS)
Tehran Iran
Universitatea din Oradea, Facultatea de Medicina
Oradea Romania
Metrikler
126
Atıf
12
Yazar
5
Anahtar Kelime