Scopus
Mechanistic insights into the role of pyroptosis in rheumatoid arthritis
Current Research in Translational Medicine · Kasım 2020
Makale Bilgileri
DergiCurrent Research in Translational Medicine
Yayın TarihiKasım 2020
Cilt / Sayfa68 · 151-158
Scopus ID2-s2.0-85089562861
Özet
Cell death is ascribed as an essential biological process that is fundamental for the development of an organism along with its survival. The procedure comprises of apoptosis and pyroptosis. Pyroptosis is a programmed procedure for cell death which is inflammatory in nature and this pathway gets activated via human caspase-4, human caspase-11 and human caspase-5. The activation of this process leads to release of pro-inflammatory mediators including cytokines, alarmins, IL-18 and IL-1β. The pro-inflammatory mediators released via interaction of intracellular kinases direct the development of Rheumatoid arthritis. Rheumatoid arthritis is characterized as disorder/disease that is auto-immune and chronic in nature. It involves erosions in marginal bone along with articular cartilage which is responsible for joint destruction. The cytokine along with its complex network is responsible for inflammation. The process of pyroptosis is linked with the destruction of plasma membrane, that releases these mediators and excessive release of these mediators is linked with rheumatoid arthritis.
Yazarlar (11)
1
Swati Chadha
2
Tapan Behl
3
Simona Bungau
4
Arun Kumar
5
Rashmi Arora
6
Amit Gupta
7
Md Sahab Uddin
8
Gokhan Zengin
ORCID: 0000-0001-6548-7823
9
Lotfi Aleya
10
Dhruv Setia
11
Sandeep Arora
Anahtar Kelimeler
Gasmerdin D
Interleukin-18
Pro-inflammatory mediators
Pyroptosis
Rheumatoid arthritis
Kurumlar
Chitkara University, Punjab
Rajpura India
Pharmakon Neuroscience Research Network
Dhaka Bangladesh
Selçuk Üniversitesi
Selçuklu Turkey
Southeast University, Dhaka
Dhaka Bangladesh
Universitatea din Oradea, Facultatea de Medicina
Oradea Romania
Université Bourgogne Franche-Comté
Besancon France
Metrikler
33
Atıf
11
Yazar
5
Anahtar Kelime