Scopus
YÖKSİS Eşleşti
Network analysis, chemical characterization, antioxidant and enzyme inhibitory effects of foxglove (Digitalis cariensis Boiss. ex Jaub. & Spach): A novel raw material for pharmaceutical applications
Journal of Pharmaceutical and Biomedical Analysis · Kasım 2020
YÖKSİS Kayıtları
Network analysis, chemical characterization, antioxidant and enzyme inhibitory effects of foxglove (Digitalis cariensis Boiss. ex Jaub. & Spach): A novel raw material for pharmaceutical applications
Journal of Pharmaceutical and Biomedical Analysis · 2020 SCI-Expanded
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Makale Bilgileri
DergiJournal of Pharmaceutical and Biomedical Analysis
Yayın TarihiKasım 2020
Cilt / Sayfa191
Scopus ID2-s2.0-85091562676
Özet
The present study outlines the phenolic composition and pharmacological properties of different extracts of Digitalis cariensis Boiss. ex Jaub. & Spach root and aerial parts. The metabolic profiles of the studied extracts were characterized by UHPLC-MS. The in vitro antioxidant and enzyme (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase) inhibitory potential of the extracts were determined. Bioinformatics and docking investigations were also conducted to support the enzyme inhibition test and predict putative targets for potential pharmacological applications. Overall, the methanolic extract followed by the water extract of the D. cariensis root were found to be superior source of antioxidant compounds except for metal chelating ability, in which the water extract of the root (26.34 ± 1.54 mg EDTAE/g) and aerial parts (16.47 ± 0.88 mg EDTAE/g) have showed the highest activity. The tested extracts were potent against AChE (9.11 ± 0.27–9.79 ± 0.28 mg GEs/g extract), α-amylase (0.12 ± 0.01- 0.50 ± 0.01 mmol ACEs/g extract) and α-glucosidase (0.28 ± 0.01–17.29 ± 0.24 mmol ACEs/ g extract). Notable activity against tyrosinase was displayed by the methanolic extracts (Root-MeOH: 123.71 ± 2.70 and aerial parts - MeOH: 137.96 ± 1.07 mg KAE/g extract), while none of the extracts were potent against BChE. According to docking investigations, the observed anti-tyrosinase effect could be related, at least partially, to the presence of luteolin, rosmarinic acid and kaempferol in the extracts. Results amassed herein is the first report on the biological attributes of D. cariensis, which validate the pharmacological uses of this plant.
Yazarlar (14)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Ramazan Ceylan
3
Kouadio Ibrahime Sinan
4
Gunes Ak
5
Sengul Uysal
6
Mohamad Fawzi Mahomoodally
7
Devina Lobine
8
Abdurrahman Aktumsek
9
Zoltán Cziáky
10
József Jekő
11
Tapan Behl
12
Giustino Orlando
13
Luigi Menghini
ORCID: 0000-0002-7346-7395
14
Claudio Ferrante
Anahtar Kelimeler
Antioxidants
Chemical fingerprints
Enzyme inhibitors
Foxglove
Network analysis
Kurumlar
Chitkara University, Punjab
Rajpura India
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
University of Nyíregyháza
Nyíregyháza Hungary
Metrikler
10
Atıf
14
Yazar
5
Anahtar Kelime