Scopus
🔓 Açık Erişim
Exploring the multifaceted therapeutic potential of withaferin a and its derivatives
Biomedicines · Aralık 2020
Makale Bilgileri
DergiBiomedicines
Yayın TarihiAralık 2020
Cilt / Sayfa8 · 1-24
Scopus ID2-s2.0-85097621967
Erişim🔓 Açık Erişim
Özet
Withaferin A (WA), a manifold studied, C28-steroidal lactone withanolide found in Withania somnifera. Given its unique beneficial effects, it has gathered attention in the era of modern science. Cancer, being considered a “hopeless case and the leading cause of death worldwide, and the available conventional therapies have many lacunae in the form of side effects. The poly pharmaceutical natural compound, WA treatment, displayed attenuation of various cancer hallmarks by altering oxidative stress, promoting apoptosis, and autophagy, inhibiting cell proliferation, reducing angiogenesis, and metastasis progression. The cellular proteins associated with antitumor pathways were also discussed. WA structural modifications attack multiple signal transduction pathways and enhance the therapeutic outcomes in various diseases. Moreover, it has shown validated pharmacological effects against multiple neurodegenerative diseases by inhibiting acetylcholesterinases and butyrylcholinesterases enzyme activity, antidiabetic activity by upregulating adiponectin and preventing the phosphorylation of peroxisome proliferator-activated receptors (PPARγ), cardioprotective activity by AMP-activated protein kinase (AMPK) activation and suppressing mitochondrial apoptosis. The current review is an extensive survey of various WA associated disease targets, its pharmacokinetics, synergistic combination, modifications, and biological activities.
Yazarlar (8)
1
Tapan Behl
2
Aditi Sharma
3
Lalit Sharma
4
Aayush Sehgal
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
6
Roxana Brata
7
Ovidiu Fratila
8
Simona Bungau
Anahtar Kelimeler
Anticancer
Autophagy
Chaperone
Withaferin A
Kurumlar
Chitkara University, Punjab
Rajpura India
Selçuk Üniversitesi
Selçuklu Turkey
Shoolini University
Solan India
Universitatea din Oradea, Facultatea de Medicina
Oradea Romania
Metrikler
58
Atıf
8
Yazar
4
Anahtar Kelime