Scopus
🔓 Açık Erişim
The lipid paradox as a metabolic checkpoint and its therapeutic significance in ameliorating the associated cardiovascular risks in rheumatoid arthritis patients
International Journal of Molecular Sciences · Aralık 2020
Makale Bilgileri
DergiInternational Journal of Molecular Sciences
Yayın TarihiAralık 2020
Cilt / Sayfa21 · 1-27
Scopus ID2-s2.0-85097788992
Erişim🔓 Açık Erişim
Özet
While the most common manifestations associated with rheumatoid arthritis (RA) are synovial damage and inflammation, the systemic effects of this autoimmune disorder are life-threatening, and are prevalent in 0.5–1% of the population, mainly associated with cardiovascular disorders (CVDs). Such effects have been instigated by an altered lipid profile in RA patients, which has been reported to correlate with CV risks. Altered lipid paradox is related to inflammatory burden in RA patients. The review highlights general lipid pathways (exogenous and endogenous), along with the changes in different forms of lipids and lipoproteins in RA conditions, which further contribute to elevated risks of CVDs like ischemic heart disease, atherosclerosis, myocardial infarction etc. The authors provide a deep insight on altered levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TGs) in RA patients and their consequence on the cardiovascular health of the patient. This is followed by a detailed description of the impact of anti-rheumatoid therapy on the lipid profile in RA patients, comprising DMARDs, corticosteroids, anti-TNF agents, anti-IL-6 agents, JAK inhibitors and statins. Furthermore, this review elaborates on the prospects to be considered to optimize future investigation on management of RA and treatment therapies targeting altered lipid paradigms in patients.
Yazarlar (9)
1
Tapan Behl
2
Ishnoor Kaur
3
Aayush Sehgal
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Ciprian Brisc
6
Mihaela Cristina Brisc
7
Mihai Alexandru Munteanu
8
Delia Carmen Nistor-Cseppento
9
Simona Bungau
Anahtar Kelimeler
Atherosclerosis
Cardiovascular disorders
DMARDs
HDL-C
Inflammatory burden
LDL-C
Lipid paradox
Lipoproteins
Rheumatoid arthritis
Kurumlar
Chitkara University, Punjab
Rajpura India
Selçuk Üniversitesi
Selçuklu Turkey
Universitatea din Oradea, Facultatea de Medicina
Oradea Romania
Metrikler
31
Atıf
9
Yazar
9
Anahtar Kelime