Scopus
YÖKSİS ISSN Eşleşti
SJR Q1
A UHPLC-QTOF-MS screening provides new insights into the phytochemical composition and biological properties of six Consolida species from Turkey
Industrial Crops and Products · Aralık 2020
YÖKSİS Kayıtları — ISSN Eşleşmesi
A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer skin diseases and type II diabetes
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HPLC DAD analysis of phenolic compounds and antioxidant properties of Asphodeline lutea roots from Bulgaria and Turkey
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A phytochemical study on Potentilla anatolica An endemic Turkish plant
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Phenolic constituent antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L from Turkey A phytochemical study
2015 ISSN: 09266690 SCI-Expanded
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Composition antioxidant antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies subsp vulgare and subsp hirtum essential oils
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
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2014 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Chemical and biological fingerprints of two Fabaceae species Cytisopsis dorycniifolia and Ebenus hirsuta Are they novel sources of natural agents for pharmaceutical and food formulations
2016 ISSN: 09266690 SCI-Expanded
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A study on in vitro enzyme inhibitory properties of Asphodeline anatolica New sources of natural inhibitors for public health problems
2016 ISSN: 09266690 SCI-Expanded
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Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response
2016 ISSN: 09266690 SCI
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Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
2018 ISSN: 09266690 SCI-Expanded
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2018 ISSN: 0926-6690 SCI-Expanded Q1
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2018 ISSN: 0926-6690 SCI-Expanded
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Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
2018 ISSN: 0926-6690 SCI-Expanded
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2018 ISSN: 0926-6690 SCI-Expanded
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2018 ISSN: 0926-6690 SCI-Expanded
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Makale Bilgileri
ISSN09266690
Yayın TarihiAralık 2020
Cilt / Sayfa158
Scopus ID2-s2.0-85091764107
Özet
The genus Consolida is one of the most important within the Ranunculaceae family and several members of this genus contain important biologically active compounds, such as phenolics and alkaloids. The present study attempts for the first time to assess the biological properties and phytochemical constituents of six Consolida species (C. glandulosa (Boiss. & A. Huet) Bornm, C. hellospontica (Boiss.) Chater, C. raveyi (Boiss.) Schrödinger, C. regalis (Boiss.) Schrödinger, C. staminosa P.H. Davis & Sorger and C. stenocarpa (P.H. Davis & M. Hossain) P.H. Davis) growing in Turkey. A comprehensive phytochemical profiling of the different species was achieved by using an ultra-high-performance liquid chromatography-quadrupole time-of-flight (UHPLC-QTOF) mass spectrometry, targeting polyphenols and diterpene alkaloids. Also, the in vitro antioxidant assays (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), metal chelating and phosphomolybdenum) and enzyme inhibition (cholinesterases, tyrosinase, α-amylase, and α-glucosidase) potentials of the different Consolida methanolic extracts were evaluated. The UHPLC-QTOF profiling revealed 492 compounds, being 236 flavonoids, 93 phenolic acids, 78 tyrosol derivatives, 49 diterpene alkaloids, 29 lignans, and 7 stilbenes. The cumulative phenolic content ranged from 17.65 mg Eq./g for C. staminosa up to 43.04 mg Eq./g for C. glandulosa, whilst the total diterpene alkaloids content was exclusively found in C. glandulosa extracts (3.53 mg Eq./g). Consolida regalis (58. 61 mg trolox equivalent (TE)/g for DPPH and 65.38 mg TE/g for ABTS) and C. stenocarpa (46.81 mg TE/g for DPPH and 78.12 mg TE/g for ABTS) exhibited the highest anti-radical abilities, while the best reducing power values were recorded for C. glandulosa (129.46 mg TE/g for CUPRAC and 77.01 mg TE/g for FRAP) and C. raveyi (124.56 mg TE/g for CUPRAC and 78.36 mg TE/g for FRAP). Also, following the cholinesterases inhibition assays, C. hellospontica and C. glandulosa exhibited the highest inhibitory effects. Regarding tyrosinase inhibitory effects, C. raveyi showed the highest value, being 126.60 mg kojic acid equivalent (KAE)/g, followed by C. glandulosa (125.82 mg KAE/g) and C. stenocarpa (123.09 mg KAE/g). Besides, Consolida staminosa showed potential inhibition against α-amylase, but low glucosidase inhibitory properties. Therefore, the present findings could provide a starting point for further investigations to promote the industrial exploitation of these species with the aim of designing novel phyto-pharmaceuticals.
Yazarlar (10)
1
Gabriele Rocchetti
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Yavuz Selim Cakmak
4
Mohamad Fawzi Mahomoodally
5
Muhammed Fettah Kaya
6
Sarah Mohammed Alsheikh
7
Jasmina Glamocilja
8
Marina Soković
ORCID: 0000-0002-7381-756X
9
Devina Lobine
10
Luigi Lucini
ORCID: 0000-0002-5133-9464
Anahtar Kelimeler
Antibacterial activity
Antifungal properties
Antioxidants
Consolida
Enzyme inhibition
Flavonoids
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Duy Tan University
Da Nang Viet Nam
Selçuk Üniversitesi
Selçuklu Turkey
Università Cattolica del Sacro Cuore, Campus di Piacenza e Cremona
Piacenza Italy
University of Belgrade
Belgrade Serbia
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Industrial Crops and Products
Q1
SJR Skoru0,974
H-Index186
YayıncıElsevier B.V.
ÜlkeNetherlands
Agronomy and Crop Science (Q1)
Metrikler
5
Atıf
10
Yazar
6
Anahtar Kelime