Scopus
YÖKSİS Eşleşti
Preliminary investigation on chemical composition and bioactivity of differently obtained extracts from Symphytum aintabicum Hub.- Mor. &Wickens
Biochemical Systematics and Ecology · Şubat 2021
YÖKSİS Kayıtları
Preliminary investigation on chemical composition and bioactivity of differently obtained extracts from Symphytum aintabicum Hub.- Mor. &Wickens
Biochemical Systematics and Ecology · 2021 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiBiochemical Systematics and Ecology
Yayın TarihiŞubat 2021
Cilt / Sayfa94
Scopus ID2-s2.0-85097232055
Özet
Symphytum species, commonly known as comfrey, hold a long history of folk medicinal uses for healing wounds, bone fractures and other pain resulting from inflammation. However, many species belonging to this genus have not yet been scientifically investigated and hence investigation in this regard is warranted. In the present research, S. aintabicum extracts prepared by different extraction techniques (homogenizer assisted extraction, infusion and maceration) were assayed for their chemosystematic attributes (total phenolic, flavonoid) as well as bioactive compound contents, antioxidant and enzyme inhibition potentials. For instance, the extracts were found to possess phenolic and flavonoid levels ranging from 35.50 to 112.25 mg GAE/g and 2.54–25.12 mg RE/g, respectively. In general, the extracts displayed significant antioxidant activity. However, methanolic and infusion extracts were observed as the most potent radical scavengers and reducing agents, most likely related to their phenolic content. The extracts also showed metal chelating power and total antioxidant capacity in phosphomolybdenum assay. Moreover, while all extracts showed inhibition on amylase, only the methanolic extracts acted as inhibitors of cholinesterases and tyrosinase, most probably due to their relatively higher flavonoid content. The findings also indicated that the extraction method as well as the solvent type used to more or less affect the yield of the bioactive compounds and extracts’ bioactivity reported herein. Hence, as a first report highlighting the in vitro pharmacological properties of S. aintabicum, promising results were revealed from the quantitative chemosystematic analysis of bioactive components present and as sources of antioxidants and enzyme inhibitors against key human illnesses, thus providing scope for potential applications in phytomedicine development.
Yazarlar (11)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Kouadio Ibrahime Sinan
3
Gunes Ak
4
Simone Angeloni
5
Filippo Maggi
ORCID: 0000-0003-1375-4744
6
Giovanni Caprioli
ORCID: 0000-0002-5530-877X
7
Alevcan Kaplan
8
Ugur Cakilcioglu
9
Hasan Akan
ORCID: 0000-0002-3033-4349
10
Sharmeen Jugreet
11
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Antioxidant
Enzyme inhibitors
Flavonoid
HPLC-MS
phenolic
Symphytum aintabicum
Kurumlar
Batman University
Batman Turkey
Harran Üniversitesi
Sanliurfa Turkey
International Hub for Coffee Research and Innovation
Belforte del Chienti (MC) Italy
Munzur University
Tunceli Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Ton-Duc-Thang University
Ho Chi Minh City Viet Nam
Università degli Studi di Camerino
Camerino Italy
University of Mauritius
Reduit Mauritius
Metrikler
11
Atıf
11
Yazar
6
Anahtar Kelime