Scopus
YÖKSİS Eşleşti
An insight into Verbascum bombyciferum extracts: Different extraction methodologies, biological abilities and chemical profiles
Industrial Crops and Products · Mart 2021
YÖKSİS Kayıtları
An insight into Verbascum bombyciferum extracts: Different extraction methodologies, biological abilities and chemical profiles
Industrial Crops and Products · 2021 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiIndustrial Crops and Products
Yayın TarihiMart 2021
Cilt / Sayfa161
Scopus ID2-s2.0-85098170412
Özet
The genus Verbascum, commonly known as "mullein", bears several species traditionally used to treat various infections, inflammations and wounds. In this study, extracts from V. bombyciferum, an endemic Verbascum species from Turkey, obtained by different solvents and extraction techniques, were investigated for their bioactive contents using spectrophotometry and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and evaluated for their antioxidant, as well as enzyme inhibitory potentials. While spectrophotometric determination revealed the homogenizer assisted extraction/methanolic extract to yield the highest total phenolic and flavonoid contents (41.80 ± 0.70 mg GAE/g and 39.44 ± 0.30 mg RE/g, respectively), the most significant total bioactive compounds (polyphenols) in the amount of 272.862 mg kg−1, established by HPLC-MS/MS analysis, was noted for the maceration/methanolic extract. Overall, the extracts showed varied antioxidant potency, displaying free radical scavenging ability (DPPH assay: 1.04–51.33 mg TE/g; ABTS assay: 80.04–85.60 mg TE/g), reducing power (CUPRAC: 51.48–183.26 mg TE/g; FRAP: 36.33–90.04 mg TE/g; metal chelating activity (18.48–19.80 mg EDTAE/g) and total antioxidant capacity (phosphomolybdenum assay: 0.78–1.92 mmol TE/g). However, extract of homogenizer assisted extraction/methanol exhibited the highest antioxidant activity in most assays. Only the maceration/methanolic extract inhibited all the studied enzymes (acetylcholinetserase: 2.02 ± 0.20 mg GALAE/g; butyrylcholinesterase: 4.57 ± 0.09 mg GALAE/g; tyrosinase 21.44 ± 3.41 mg KAE/g and amylase: 0.46 ± 0.01 mmol ACAE/g). This study is the first attempt to highlight the potential industrial applications of the endemic plant V. bombyciferum, as a natural source of bioactive compounds that could be considered for future development of phytopharmaceuticals, targeting specific oxidative stress-linked diseases including diabetes, skin hyperpigmentation, and neurological disorders.
Yazarlar (12)
1
Simone Angeloni
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Kouadio Ibrahime Sinan
4
Gunes Ak
5
Filippo Maggi
ORCID: 0000-0003-1375-4744
6
Giovanni Caprioli
ORCID: 0000-0002-5530-877X
7
Alevcan Kaplan
8
Muammer Bahşi
9
Ugur Cakilcioglu
10
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
11
Sharmeen Jugreet
12
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Antioxidant
Enzyme inhibition
Phytopharmaceutics
Polyphenols
Verbascum bombyciferum
Kurumlar
Batman University
Batman Turkey
Faculté des Sciences Rabat
Rabat Morocco
Firat Üniversitesi
Elazig Turkey
International Hub for Coffee Research and Innovation
Belforte del Chienti (MC) Italy
Munzur University
Tunceli Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Ton-Duc-Thang University
Ho Chi Minh City Viet Nam
Università degli Studi di Camerino
Camerino Italy
University of Mauritius
Reduit Mauritius
Metrikler
8
Atıf
12
Yazar
5
Anahtar Kelime