Scopus
YÖKSİS Eşleşti
A comparative study on biological properties and chemical profiles of different solvent extracts from Centaurea bingoelensis, an endemic plant of Turkey
Process Biochemistry · Mart 2021
YÖKSİS Kayıtları
A comparative study on biological properties and chemical profiles of different solvent extracts from Centaurea bingoelensis, an endemic plant of Turkey
Process Biochemistry · 2021 SCI-Expanded
PROFESÖR AHMET UYSAL →
Makale Bilgileri
DergiProcess Biochemistry
Yayın TarihiMart 2021
Cilt / Sayfa102 · 315-324
Scopus ID2-s2.0-85100396254
Özet
This study focused on the biological evaluation and chemical characterization of Centaurea bingoelensis, an endemic plant to Turkey. Different solvent extracts (hexane, dichloromethane (DCM), ethyl acetate (EA), methanol, hydro-methanol, and water extracts) were prepared. The antioxidant, enzyme inhibitory, antimicrobial and cytotoxic activities were investigated. The hydro-methanol extract, possessing high phenolic content (41.57 mg gallic acid equivalent (GAE)/g extract), showed highest reducing capacity (136.87 and 82.16 mg Trolox equivalent[TE]/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant power, respectively) and radical scavenging potential (70.72 and 76.53 mg TE/g extract, against 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), respectively). Ultra performance liquid chromatography - tandem mass spectrometer (UHPLC/MS/MS) analysis revealed the presence of 67 and 62 compounds in the methanolic and water extracts, respectively. According to the broth microdilution results, DCM and EA extracts showed significant antimicrobial activity with Sarcina lutea being the most sensitive bacterium to the extracts (MIC = 0.19 (DCM) and 0.097 mg/mL (EA)). Most extracts showed promising antifungal activity against Candida albicans. The methanol extract was most toxic against human hepatocarcinoma (HepG2) cells, and also significantly reduced the cell viability of the non-tumoral murine bone marrow stromal (S17) cells. This study has provided valuable scientific data on this endemic plant which can be considered as a promising candidate for the development of novel phyto-pharmaceuticals.
Yazarlar (12)
1
Ahmet Uysal
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Mohamad Fawzi Mahomoodally
4
Carene Marie Nancy Picot-Allain
5
József Jekő
6
Zoltán Cziáky
7
Maria João Rodrigues
8
Gunes Ak
9
Rıdvan Polat
10
Zeynep Urusan
11
Kouadio Ibrahime Sinan
12
Luisa Custodio
Anahtar Kelimeler
Antioxidants
Biological activities
Centaurea
Extracts
Natural agents
Kurumlar
Bingöl Üniversitesi
Bingol Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Ton-Duc-Thang University
Ho Chi Minh City Viet Nam
Universidade do Algarve
Faro Portugal
University of Mauritius
Reduit Mauritius
University of Nyíregyháza
Nyíregyháza Hungary
Metrikler
18
Atıf
12
Yazar
5
Anahtar Kelime