Scopus
YÖKSİS Eşleşti
UHPLC-QTOF-MS based metabolomics and biological activities of different parts of Eriobotrya japonica
Food Research International · Mayıs 2021
YÖKSİS Kayıtları
UHPLC-QTOF-MS based metabolomics and biological activities of different parts of Eriobotrya japonica
Food Research International · 2021 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiFood Research International
Yayın TarihiMayıs 2021
Cilt / Sayfa143
Scopus ID2-s2.0-85102278750
Özet
Eriobotrya japonica, commonly known as loquat, has been used traditionally for the treatment of different diseases. Herein, untargeted profiling based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) was used to depict the phytochemical profile of loquat roots, leaves, stems, seeds, and fruits. This allowed the tentative annotation of 349 compounds, representing different phytochemical classes that included flavonoids, phenolic acids, lignans, stilbenes, and terpenoids. Among others, low molecular weight phenolics (tyrosol derivatives) and terpenoids were the most abundant phytochemicals. After that, in vitro antioxidant and enzyme inhibition assays were applied to investigate the biological activity of the different organs of Eriobotrya japonica. Roots of E. japonica exhibited the highest antioxidant capacity, showing 181.88, 275.48, 325.18, 169.74 mg Trolox equivalent (TE)/g in DPPH, ABTS, CUPRAC, and FRAP assays, respectively. Furthermore, the root extract of E. japonica strongly inhibited butyryl cholinesterase (3.64 mg galantamine equivalent (GALAE)/g), whereas leaves, stems, seeds, and fruits showed comparable inhibition of both acetyl and butyryl cholinesterases. All the investigated organs of E. japonica exhibited in vitro tyrosinase inhibition (57.27–71.61 mg Kojic Acid Equivalent (KAE)/g). Our findings suggest a potential food and pharmaceutical exploitation of different organs of E. japonica (mainly roots) in terms of enrichment with health-promoting phenolics and triterpenes.
Yazarlar (6)
1
Leilei Zhang
ORCID: 0000-0002-9278-0459
2
Fatema R. Saber
3
Gabriele Rocchetti
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Mona M. Hashem
6
Luigi Lucini
ORCID: 0000-0002-5133-9464
Anahtar Kelimeler
Antioxidants
Loquat
Nutraceuticals
Phytochemical profiling
Rosaceae
UHPLC-QTOF-MS
Kurumlar
Cairo University
Giza Egypt
Selçuk Üniversitesi
Selçuklu Turkey
Università Cattolica del Sacro Cuore, Campus di Piacenza e Cremona
Piacenza Italy
Metrikler
17
Atıf
6
Yazar
6
Anahtar Kelime