Scopus
🔓 Açık Erişim
Current perspective on the natural compounds and drug delivery techniques in glioblastoma multiforme
Cancers · Haziran 2021
Makale Bilgileri
DergiCancers
Yayın TarihiHaziran 2021
Cilt / Sayfa13
Scopus ID2-s2.0-85106983335
Erişim🔓 Açık Erişim
Özet
Glioblastoma multiforme (GBM) is one of the debilitating brain tumors, being associated with extremely poor prognosis and short median patient survival. GBM is associated with complex pathogenesis with alterations in various cellular signaling events, that participate in cell proliferation and survival. The impairment in cellular redox pathways leads to tumorigenesis. The current standard pharmacological regimen available for glioblastomas, such as radiotherapy and surgical resection following treatment with chemotherapeutic drug temozolomide, remains fatal, due to drug resistance, metastasis and tumor recurrence. Thus, the demand for an effective therapeutic strategy for GBM remains elusive. Hopefully, novel products from natural compounds are suggested as possible solutions. They protect glial cells by reducing oxidative stress and neuroinflammation, inhibiting proliferation, inducing apoptosis, inhibiting pro‐oncogene events and intensifying the potent anti‐tumor therapies. Targeting aberrant cellular pathways in the amelioration of GBM could promote the development of new therapeutic options that improve patient quality of life and extend survival. Consequently, our review emphasizes several natural compounds in GBM treatment. We also assessed the potential of drug delivery techniques such as nanoparticles, Gliadel wafers and drug delivery using cellular carriers which could lead to a novel path for the obliteration of GBM.
Yazarlar (13)
1
Tapan Behl
2
Aditi Sharma
3
Lalit Sharma
4
Aayush Sehgal
5
Sukhbir Singh
6
Neelam Sharma
7
Gokhan Zengin
ORCID: 0000-0001-6548-7823
8
Simona Bungau
9
Mirela Marioara Toma
10
Daniela Gitea
11
Elena Emilia Babes
12
Claudia Teodora Judea Pusta
13
Adrian Gheorghe Bumbu
Anahtar Kelimeler
Drug delivery techniques
Flavonoids
Glioblastoma multiforme
Natural compounds
Oxidative stress
Therapeutic potential
Kurumlar
Chitkara University, Punjab
Rajpura India
Selçuk Üniversitesi
Selçuklu Turkey
Shoolini University
Solan India
Universitatea din Oradea, Facultatea de Medicina
Oradea Romania
University of Oradea
Oradea Romania
Metrikler
47
Atıf
13
Yazar
6
Anahtar Kelime