Scopus
🔓 Açık Erişim
Role of monoamine oxidase activity in alzheimer’s disease: An insight into the therapeutic potential of inhibitors
Molecules · Haziran 2021
Makale Bilgileri
DergiMolecules
Yayın TarihiHaziran 2021
Cilt / Sayfa26
Scopus ID2-s2.0-85108854540
Erişim🔓 Açık Erişim
Özet
Despite not being utilized as considerably as other antidepressants in the therapy of depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in neurodegeneration and to have a somewhat broad spectrum in respect of the treatment of neurological and psychiatric conditions. Preclinical and clinical studies on MAOIs have been developing in recent times, especially on account of rousing discoveries manifesting that these drugs possess neuroprotective activities. The altered brain levels of monoamine neurotransmitters due to monoamine oxidase (MAO) are directly associated with various neuropsychiatric conditions like Alzheimer’s disease (AD). Activated MAO induces the amyloid-beta (Aβ) deposition via abnormal cleavage of the amyloid precursor protein (APP). Additionally, activated MAO contributes to the generation of neurofibrillary tangles and cognitive impairment due to neuronal loss. No matter the attention of researchers on the participation of MAOIs in neuroprotection has been on monoamine oxidase-B (MAO-B) inhibitors, there is a developing frame of proof indicating that monoamine oxidase-A (MAO-A) inhibitors may also play a role in neuroprotection. The therapeutic potential of MAOIs alongside the complete understanding of the enzyme’s physiology may lead to the future advancement of these drugs.
Yazarlar (10)
1
Tapan Behl
2
Dapinder Kaur
3
Aayush Sehgal
4
Sukhbir Singh
5
Neelam Sharma
6
Gokhan Zengin
ORCID: 0000-0001-6548-7823
7
Felicia Liana Andronie-Cioara
8
Mirela Marioara Toma
9
Simona Bungau
10
Adrian Gheorghe Bumbu
Anahtar Kelimeler
Alzheimer’s disease
Monoamine oxidase
Monoamine oxidase inhibitors
Monoaminergic neurotransmitters
Neuroinflammation
Oxidative stress
Reactive aldehydes
Kurumlar
Chitkara University, Punjab
Rajpura India
Selçuk Üniversitesi
Selçuklu Turkey
Universitatea din Oradea, Facultatea de Medicina
Oradea Romania
University of Oradea
Oradea Romania
Metrikler
139
Atıf
10
Yazar
7
Anahtar Kelime