Scopus
🔓 Açık Erişim
Current trends in neurodegeneration: Cross talks between oxidative stress, cell death, and inflammation
International Journal of Molecular Sciences · Temmuz 2021
Makale Bilgileri
DergiInternational Journal of Molecular Sciences
Yayın TarihiTemmuz 2021
Cilt / Sayfa22
Scopus ID2-s2.0-85109296293
Erişim🔓 Açık Erişim
Özet
The human body is highly complex and comprises a variety of living cells and extracellular material, which forms tissues, organs, and organ systems. Human cells tend to turn over readily to maintain homeostasis in tissues. However, postmitotic nerve cells exceptionally have an ability to regenerate and be sustained for the entire life of an individual, to safeguard the physiological functioning of the central nervous system. For efficient functioning of the CNS, neuronal death is essential, but extreme loss of neurons diminishes the functioning of the nervous system and leads to the onset of neurodegenerative diseases. Neurodegenerative diseases range from acute to chronic severe life-altering conditions like Parkinson’s disease and Alzheimer’s disease. Millions of individuals worldwide are suffering from neurodegenerative disorders with little or negligible treatment available, thereby leading to a decline in their quality of life. Neuropathological studies have identified a series of factors that explain the etiology of neuronal degradation and its progression in neurodegenerative disease. The onset of neurological diseases depends on a combination of factors that causes a disruption of neurons, such as environmental, biological, physiological, and genetic factors. The current review highlights some of the major pathological factors responsible for neuronal degradation, such as oxidative stress, cell death, and neuroinflammation. All these factors have been described in detail to enhance the understanding of their mechanisms and target them for disease management.
Yazarlar (12)
1
Tapan Behl
2
Rashita Makkar
3
Aayush Sehgal
4
Sukhbir Singh
5
Neelam Sharma
6
Gokhan Zengin
ORCID: 0000-0001-6548-7823
7
Simona Bungau
8
Felicia Liana Andronie-Cioara
9
Mihai Alexandru Munteanu
10
Mihaela Cristina Brisc
11
Diana Uivarosan
12
Ciprian Brisc
Anahtar Kelimeler
Apoptosis
Cell death
Necrosis
Neurodegeneration
Neuroinflammation
Oxidative stress
Kurumlar
Chitkara University, Punjab
Rajpura India
Selçuk Üniversitesi
Selçuklu Turkey
Universitatea din Oradea, Facultatea de Medicina
Oradea Romania
University of Oradea
Oradea Romania
Metrikler
65
Atıf
12
Yazar
6
Anahtar Kelime