Scopus
YÖKSİS Eşleşti
A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis
Chemistry and Biodiversity · Ağustos 2021
YÖKSİS Kayıtları
A ProspectiveofMultipleBiopharmaceuticalActivitiesofProcyanidins-RichUapacatogoensisPaxExtracts:HPLC-ESI-TOF-MSCoupledwithBioinformaticsAnalysis
Chemistry & Biodiversity · 2021 SCI-Expanded
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Makale Bilgileri
DergiChemistry and Biodiversity
Yayın TarihiAğustos 2021
Cilt / Sayfa18
Scopus ID2-s2.0-85108354561
Özet
The article reports the chemical composition, antioxidant, six key enzymes inhibitory and antimicrobial activities of two solvent extracts (water and methanol) of leaves and stem bark of Uapaca togoensis. For chemical composition, methanol extract of stem bark exhibited significant higher total phenolic (129.86 mg GAE/g) and flavanol (10.44 mg CE/g) contents. Methanol extract of leaves and water extract of stem bark showed high flavonoids (20.94 mg RE/g) and phenolic acid (90.40 mg CAE/g) content, respectively. In addition, HPLC-ESI-TOF-MS analysis revealed that U. togoensis was rich in procyanidins. The methanol and water extracts of stem bark had overall superior antioxidant activity; however, only methanol extract of stem bark showed higher inhibition of cholinesterase (AChE: 2.57 mg GALAE/g; BChE: 4.69 mg GALAE/g), tyrosinase (69.53 mg KAE/g) and elastase (2.73 mmol CE/g). Potent metal chelating ability was showed by water extract of leaves (18.94 mg EDTAE/g), higher inhibition of amylase was detected for water extracts of leaves (0.94 mmol ACAE/g) and stem bark (0.92 mmol ACAE/g). The tested extracts have shown wide-spectrum antibacterial properties and these effects have shown to be more effective against Aspergillus ochraceus, Penicillium funiculosum, Trichoderma viride, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The results revealed that the antioxidant, enzyme inhibitory and antimicrobial activities depended on the extraction solvents and the parts of plant. Bioinformatics analysis on the 17 major compounds showed modulation of pathway associated with cancer. In brief, U. togoensis might be valuable as potential source of natural agents for therapeutic application.
Yazarlar (10)
1
Kouadio Ibrahime Sinan
2
Abdurrahman Aktumsek
3
María de la Luz Cádiz-Gurrea
4
Francisco Javier Leyva-Jiménez
5
Álvaro Fernández-Ochoa
6
Antonio Segura-Carretero
ORCID: 0000-0002-5564-5338
7
Jasmina Glamocilja
8
Marina Soković
ORCID: 0000-0002-7381-756X
9
Marija Nenadić
10
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
antimicrobial activity
antioxidant agents
KEGG enrichment analysis
procyanidins
Uapaca togoensis
Kurumlar
Berliner Institut für Gesundheitsforschung
Berlin Germany
Functional Food Research and Development Center
Granada Spain
Max Delbruck Center for Molecular Medicine
Berlin Germany
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Granada, Facultad de Ciencias
Granada Spain
University of Belgrade
Belgrade Serbia
Metrikler
6
Atıf
10
Yazar
5
Anahtar Kelime