Scopus
YÖKSİS DOI Eşleşti
SJR Q3
A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis
Chemistry and Biodiversity · Ağustos 2021
YÖKSİS Kayıtları
A ProspectiveofMultipleBiopharmaceuticalActivitiesofProcyanidins-RichUapacatogoensisPaxExtracts:HPLC-ESI-TOF-MSCoupledwithBioinformaticsAnalysis
Chemistry & Biodiversity · 2021 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential of iHaplophyllum sahinii/i and iH. vulcanicum/i Extracts/title
2019 ISSN: 1612-1872 SCI-Expanded
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Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi İREM AYRAN ÇOLAK →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. YÜKSEL KAN →
A ProspectiveofMultipleBiopharmaceuticalActivitiesofProcyanidins-RichUapacatogoensisPaxExtracts:HPLC-ESI-TOF-MSCoupledwithBioinformaticsAnalysis
2021 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
A comparative study of chemical profiling and biological effects of Doronicum orientale extracts
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Synthesis and Characterization of Copper\u2010Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. NURANİYE ERUYGUR →
Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi CEYLAN DÖNMEZ →
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential ofHaplophyllum sahiniiandH. vulcanicumExtracts
2019 ISSN: 1612-1872 SSCI
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Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
Doç. Dr. FATMA AYAZ →
Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
2022 ISSN: 1612-1872 SCI-Expanded
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Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI Q3
Prof. Dr. YÜKSEL KAN →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. MEHMET TUZCU →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
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Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
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Antioxidant and Enzyme Inhibitory Activities of Rhoifolin Flavonoid: In Vitro and in Silico Studies
2023 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. GÖKHAN ZENGİN →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Doç. Dr. FATMA AYAZ →
Enzyme Inhibitory and Antioxidant Potential with Phytochemical Analysis of Satureja hasturkii H.Duman & Dirmenci: A New Record From Türkiye
2025 ISSN: 1612-1872 SCI-Expanded
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Screening for Antioxidant Effects and Chemical Profiles of Different Extracts of Rheum ribes Parts
2025 ISSN: 1612-1872 SCI-Expanded
Prof. Dr. ATİLLA ARSLAN →
Screening for Antioxidant Effects and Chemical Profiles of Different Extracts of Rheum ribes Parts
2025 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. EMİNE ARSLAN →
Makale Bilgileri
ISSN16121872
Yayın TarihiAğustos 2021
Cilt / Sayfa18
Scopus ID2-s2.0-85108354561
Özet
The article reports the chemical composition, antioxidant, six key enzymes inhibitory and antimicrobial activities of two solvent extracts (water and methanol) of leaves and stem bark of Uapaca togoensis. For chemical composition, methanol extract of stem bark exhibited significant higher total phenolic (129.86 mg GAE/g) and flavanol (10.44 mg CE/g) contents. Methanol extract of leaves and water extract of stem bark showed high flavonoids (20.94 mg RE/g) and phenolic acid (90.40 mg CAE/g) content, respectively. In addition, HPLC-ESI-TOF-MS analysis revealed that U. togoensis was rich in procyanidins. The methanol and water extracts of stem bark had overall superior antioxidant activity; however, only methanol extract of stem bark showed higher inhibition of cholinesterase (AChE: 2.57 mg GALAE/g; BChE: 4.69 mg GALAE/g), tyrosinase (69.53 mg KAE/g) and elastase (2.73 mmol CE/g). Potent metal chelating ability was showed by water extract of leaves (18.94 mg EDTAE/g), higher inhibition of amylase was detected for water extracts of leaves (0.94 mmol ACAE/g) and stem bark (0.92 mmol ACAE/g). The tested extracts have shown wide-spectrum antibacterial properties and these effects have shown to be more effective against Aspergillus ochraceus, Penicillium funiculosum, Trichoderma viride, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The results revealed that the antioxidant, enzyme inhibitory and antimicrobial activities depended on the extraction solvents and the parts of plant. Bioinformatics analysis on the 17 major compounds showed modulation of pathway associated with cancer. In brief, U. togoensis might be valuable as potential source of natural agents for therapeutic application.
Yazarlar (10)
1
Kouadio Ibrahime Sinan
2
Abdurrahman Aktumsek
3
María de la Luz Cádiz-Gurrea
4
Francisco Javier Leyva-Jiménez
5
Álvaro Fernández-Ochoa
6
Antonio Segura-Carretero
ORCID: 0000-0002-5564-5338
7
Jasmina Glamocilja
8
Marina Soković
ORCID: 0000-0002-7381-756X
9
Marija Nenadić
10
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
antimicrobial activity
antioxidant agents
KEGG enrichment analysis
procyanidins
Uapaca togoensis
Kurumlar
Berliner Institut für Gesundheitsforschung
Berlin Germany
Functional Food Research and Development Center
Granada Spain
Max Delbruck Center for Molecular Medicine
Berlin Germany
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Granada, Facultad de Ciencias
Granada Spain
University of Belgrade
Belgrade Serbia
Scimago Dergi (ISSN Eşleşmesi)
Chemistry and Biodiversity
Q3
SJR Skoru0,425
H-Index87
YayıncıWiley-Blackwell
ÜlkeUnited States
Biochemistry (Q3)
Bioengineering (Q3)
Chemistry (miscellaneous) (Q3)
Medicine (miscellaneous) (Q3)
Molecular Biology (Q4)
Molecular Medicine (Q4)
Metrikler
7
Atıf
10
Yazar
5
Anahtar Kelime