Scopus
🔓 Açık Erişim
Unravelling the phytochemical composition and the pharmacological properties of an optimized extract from the fruit from prunus mahaleb l.: From traditional liqueur market to the pharmacy shelf
Molecules · Ağustos 2021
Makale Bilgileri
DergiMolecules
Yayın TarihiAğustos 2021
Cilt / Sayfa26
Scopus ID2-s2.0-85111589015
Erişim🔓 Açık Erişim
Özet
Prunus mahaleb L. fruit has long been used in the production of traditional liqueurs. The fruit also displayed scavenging and reducing activity, in vitro. The present study focused on unravelling peripheral and central protective effects, antimicrobial but also anti-COVID-19 properties exerted by the water extract of P. mahaleb. Anti-inflammatory effects were studied in isolated mouse colons exposed to lipopolysaccharide. Neuroprotection, measured as a blunting effect on hydrogen-peroxideinduced dopamine turnover, was investigated in hypothalamic HypoE22 cells. Antimicrobial effects were tested against different Gram+ and Gram-bacterial strains. Whereas anti-COVID-19 activity was studied in lung adenocarcinoma H1299 cells, where the gene expression of ACE2 and TMPRSS2 was measured after extract treatment. The bacteriostatic effects induced on Gram+ and Gram-strains, together with the inhibition of COX-2, TNFα, HIF1α, and VEGFA in the colon, suggest the potential of P. mahaleb water extract in contrasting the clinical symptoms related to ulcerative colitis. The inhibition of the hydrogen peroxide-induced DOPAC/DA ratio indicates promising neuroprotective effects. Finally, the downregulation of the gene expression of ACE2 and TMPRSS2 in H1299 cells, suggests the potential to inhibit SARS-CoV-2 virus entry in the human host. Overall, the results support the valorization of the local cultivation of P. mahaleb.
Yazarlar (17)
1
Giustino Orlando
2
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
3
Sabrina Adorisio
4
Domenico V. Delfino
5
Luigi Brunetti
6
Lucia Recinella
7
Sheila Leone
8
Gokhan Zengin
ORCID: 0000-0001-6548-7823
9
Alessandra Acquaviva
10
Paola Angelini
ORCID: 0000-0002-6862-1079
11
Giancarlo Angeles Flores
ORCID: 0000-0001-6651-9794
12
Roberto Venanzoni
ORCID: 0000-0002-7768-0468
13
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
14
Francesca Di Corpo
15
Andrei Mocan
16
Luigi Menghini
ORCID: 0000-0002-7346-7395
17
Claudio Ferrante
Anahtar Kelimeler
Anti-bacterial effects
Anti-COVID-19 effects
Chicoric acid
Phenolic profile
Protective effects
Prunus mahaleb L
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Perugia
Perugia Italy
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Cluj Napoca Romania
Universitatea de Stiinte Agricole si Medicina Veterinara din Cluj-Napoca
Cluj Napoca Romania
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Veridia Italia Srl
Pescara Italy
Metrikler
16
Atıf
17
Yazar
6
Anahtar Kelime