Scopus
🔓 Açık Erişim
Physiopathology and effectiveness of therapeutic vaccines against human papillomavirus
Environmental Science and Pollution Research · Eylül 2021
Makale Bilgileri
DergiEnvironmental Science and Pollution Research
Yayın TarihiEylül 2021
Cilt / Sayfa28 · 47752-47772
Scopus ID2-s2.0-85110721777
Erişim🔓 Açık Erişim
Özet
Human papillomavirus (HPV) is a well-known sexually transmitted disorder globally. Human papillomavirus (HPV) is the 3rd most common cancer that causes cervical carcinoma, and globally it accounts for 275,000 deaths every year. The load of HPV-associated abrasions can be lessened through vaccination. At present, three forms of prophylactic vaccines, Cervarix, Gadrasil, and Gardasil 9, are commercially accessible but all these prophylactic vaccines have not the ability to manage and control developed abrasions or infections. Therefore, a considerable amount of the population is not secured from HPV infectivity. Consequently, the development of therapeutic HPV vaccines is a crucial requirement of this era, for the treatment of persisting infections, and to stop the progression of HPV-associated cancers. Therapeutic vaccines are a developing trial approach. Because of the constitutive expression of E6 and E7 early genes in cancerous and pre-cancerous tissues, and their involvement in disturbance of the cell cycle, these are best targets for this therapeutic vaccine treatment. For the synthesis and development of therapeutic vaccines, various approaches have been examined comprising cell-based vaccines, peptide/protein-based vaccines, nucleic acid–based vaccines, and live-vector vaccines all proceeding towards clinical trials. This review emphasizes the development, progress, current status, and future perspective of several vaccines for the cure of HPV-related abrasions and cancers. This review also provides an insight to assess the effectiveness, safety, efficacy, and immunogenicity of therapeutic vaccines in the cure of patients infected with HPV-associated cervical cancer.
Yazarlar (12)
1
Noor Ayesha
2
Sara Aboulaghras
3
Muhammad Jahangeer
4
Areej Riasat
5
Rehana Ramzan
6
Rameen Fatima
7
Muhammad Akram
8
Abdelaali Balahbib
9
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
10
Ekaterina Sepiashvili
11
Gokhan Zengin
ORCID: 0000-0001-6548-7823
12
Mohammad Ali Shariati
ORCID: 0000-0001-9376-5771
Anahtar Kelimeler
Cervical cancer
HLA polymorphism
Papillomavirus
Pathogenesis
Vaccines
Kurumlar
Faculté des Sciences Rabat
Rabat Morocco
Government College University Faisalabad
Faisalabad Pakistan
Mohammed V University in Rabat
Rabat Morocco
Moscow State University of Technologies and Management
Moscow Russian Federation
Selçuk Üniversitesi
Selçuklu Turkey
University of Agriculture, Faisalabad
Faisalabad Pakistan
Metrikler
8
Atıf
12
Yazar
5
Anahtar Kelime