Scopus
🔓 Açık Erişim
Health benefits and pharmacological properties of hinokitiol
Processes · Eylül 2021
Makale Bilgileri
DergiProcesses
Yayın TarihiEylül 2021
Cilt / Sayfa9
Scopus ID2-s2.0-85115807306
Erişim🔓 Açık Erişim
Özet
Hinokitiol is a natural bioactive compound found in several aromatic and medicinal plants. It is a terpenoid synthetized and secreted by different species as secondary metabolites. This volatile compound was tested and explored for its different biological properties. In this review, we report the pharmacological properties of hinokitiol by focusing mainly on its anticancer mecha-nisms. Indeed, it can block cell transformation at different levels by its action on the cell cycle, apop-tosis, autophagy via inhibiting gene expression and dysregulating cellular signaling pathways. Moreover, hinokitiol also exhibits other pharmacological properties, including antidiabetic, anti-inflammatory, and antimicrobial effects. It showed multiple and several effects through its inhibi-tion, interaction and/or activation of the main cellular targets inducing these pathologies.
Yazarlar (13)
1
Naoufal El Hachlafi
ORCID: 0000-0003-0768-5914
2
Fatima Lakhdar
3
Aya Khouchlaa
4
Saad Bakrim
5
Nasreddine El Omari
6
Abdelaali Balahbib
7
Mohammad Ali Shariati
ORCID: 0000-0001-9376-5771
8
Gokhan Zengin
ORCID: 0000-0001-6548-7823
9
Kawtar Fikri-Benbrahim
10
Giustino Orlando
11
Claudio Ferrante
12
Luigi Meninghi
13
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
Anahtar Kelimeler
Cancer
Hinokitiol
NF-KB
Pharmacological action
Signaling pathways
Kurumlar
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculté des Sciences d'El Jadida
El Jadida Morocco
Faculté des Sciences Rabat
Rabat Morocco
Faculte Polydisciplinaire de Taroudant
Taroudant Morocco
Moscow State University of Technologies and Management
Moscow Russian Federation
Selçuk Üniversitesi
Selçuklu Turkey
Université Sidi Mohamed Ben Abdellah
Fez Morocco
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
24
Atıf
13
Yazar
5
Anahtar Kelime