Scopus
🔓 Açık Erişim
Insights into the phytochemical and multifunctional biological profile of spices from the genus piper
Antioxidants · Ekim 2021
Makale Bilgileri
DergiAntioxidants
Yayın TarihiEkim 2021
Cilt / Sayfa10
Scopus ID2-s2.0-85117196685
Erişim🔓 Açık Erişim
Özet
Piper spices represent an inexhaustible reservoir of bioactive compounds that may act as drug leads in natural product research. The aim of this study was to investigate a series of methanolic fruit extracts obtained from P. nigrum (black, green, white and red), P. longum and P. retro-fractum in comparative phytochemical and multi‐directional biological (antimicrobial, antioxidant, anti‐enzymatic and anti‐melanogenic) assays. The metabolite profiling revealed the presence of 17 piperamides, with a total content of 247.75–591.42 mg piperine equivalents/g. Among the 22 tested microorganism strains, Piper spices were significantly active (MIC < 0.1 mg/mL) against the anaer-obes Actinomyces israelii and Fusobacterium nucleatum. The antioxidant and anti‐enzymatic activities were evidenced in DPPH (10.64–82.44 mg TE/g) and ABTS (14.20–77.60 mg TE/g) radical scaveng-ing, CUPRAC (39.94–140.52 mg TE/g), FRAP (16.05–77.00 mg TE/g), chelating (0–34.80 mg EDTAE/g), anti‐acetylcholinesterase (0–2.27 mg GALAE/g), anti‐butyrylcholinesterase (0.60–3.11 mg GALAE/g), anti‐amylase (0.62–1.11 mmol ACAE/g) and anti‐glucosidase (0–1.22 mmol ACAE/g) assays. Several Piper extracts (10 μg/mL) inhibited both melanin synthesis (to 32.05– 60.65% of αMSH+ cells) and release (38.06–45.78% of αMSH+ cells) in αMSH‐stimulated B16F10 cells, partly explained by their tyrosinase inhibitory properties. Our study uncovers differences between Piper spices and sheds light on their potential use as nutraceuticals or cosmeceuticals for the management of different diseases linked to bacterial infections, Alzheimer’s dementia, type 2 diabetes mellitus or hyperpigmentation.
Yazarlar (10)
1
Simon Vlad Luca
ORCID: 0000-0001-8785-249X
2
Katarzyna Gaweł‐bęben
3
Marcelina Strzępek‐gomółka
4
Karolina Czech
5
Adriana Trifan
6
Gokhan Zengin
ORCID: 0000-0001-6548-7823
7
Izabela Korona-Glowniak
ORCID: 0000-0003-1634-0387
8
Mirjana Minceva
ORCID: 0000-0001-9820-7410
9
Jürg Gertsch
10
Krystyna Skalicka-Wozniak
Anahtar Kelimeler
Anti‐melanogenic
Antimicrobial
Anti‐tyrosinase
Natural bioactive agents
Piper
Piperamides
Kurumlar
Medical University of Lublin
Lublin Poland
Selçuk Üniversitesi
Selçuklu Turkey
Technische Universität München
Munich Germany
Universitatea de Medicina si Farmacie Grigore T. Popa din Iasi
Iasi Romania
University of Bern
Bern Switzerland
Wyższa Szkoła Informatyki i Zarządzania z siedzibą w Rzeszowie
Rzeszow Poland
Metrikler
12
Atıf
10
Yazar
6
Anahtar Kelime