Scopus
🔓 Açık Erişim
Phenolic analysis and in vitro biological activity of red wine, pomace and grape seeds oil derived from vitis vinifera l. Cv. montepulciano d’abruzzo
Antioxidants · Kasım 2021
Makale Bilgileri
DergiAntioxidants
Yayın TarihiKasım 2021
Cilt / Sayfa10
Scopus ID2-s2.0-85117878700
Erişim🔓 Açık Erişim
Özet
Grape pomace is commonly considered a waste product of monovarietal red wine pro-duction. Methods: HPLC-DAD analysis was performed to determine the polyphenol and flavonoid contents of all the extracts obtained from Montepulciano d’Abruzzo red wine and grape skins whereas, GC-MS was applied to the determination of fatty acid composition in grape seeds oil. Biological characterization involves antioxidant and antimicrobial assays for all the extracts and seeds oil; Their ability to inhibit α-glucosidase, α-amylase, α-tyrosinase, and ChE enzymes was also detected, together with anti-inflammatory activity on wine, grape skin extracts, and seeds oil by lipoxygenase (5-LOX) and LPS-stimulated macrophage release assays. Data indicate significative polyphenols content (199.31 ± 7.21 mgGAE/g), antioxidant (CUPRAC assay (1036.98 mgTE/g)), enzymatic inhibition (α-tyrosinase: 151.30 ± 1.20 mgKAE/g) and anti-inflammatory activities for wine-organic extract 2, while the antimicrobial activity of grape skin decoction is higher than those reported by wine extracts on three bacterial strains. Interestingly only dealcoholized wine and wine-aqueous extract exerts inhibitory effects on α-glucosidase (20.62 ± 0.23 mmolACAE/g and 19.81 ± 0.03 mmolACAE/g, respectively), while seeds oil is rich in oleic and linoleic acids. These results confirm the strong antioxidant properties of Montepulciano d’Abruzzo grape pomace, sug-gesting the potential use of this waste product as functional food supplements in the human diet and in cosmeceutics.
Yazarlar (14)
1
Adriano Mollica
2
Giuseppe Scioli
3
Alice Della Valle
4
Angelo Cichelli
5
Ettore Novellino
6
Marta Bauer
7
Wojciech Kamysz
8
E. J. Llorent-Martínez
9
Maria Luisa Fernández De Córdova
10
R. Castillo-López
11
Gunes Ak
12
Gokhan Zengin
ORCID: 0000-0001-6548-7823
13
Stefano Pieretti
14
Azzurra Stefanucci
Anahtar Kelimeler
Anti-inflammatory potential
Antimicrobial activity
Antioxidants
Enzyme inhibition
Grape pomace
Phenolic compounds
Seeds
Kurumlar
Gdanski Uniwersytet Medyczny
Gdansk Poland
Istituto Superiore Di Sanita
Rome Italy
NGN Healthcare
Mercogliano Italy
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Jaén
Jaen Spain
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
59
Atıf
14
Yazar
7
Anahtar Kelime