Scopus
Investigation on the Phytochemical Composition, Antioxidant and Enzyme Inhibition Potential of Polygonum Plebeium R.Br: A Comprehensive Approach to Disclose New Nutraceutical and Functional Food Ingredients
Chemistry and Biodiversity · Aralık 2021
Makale Bilgileri
DergiChemistry and Biodiversity
Yayın TarihiAralık 2021
Cilt / Sayfa18
Scopus ID2-s2.0-85118583864
Özet
The present work describes medicinal potential and secondary metabolic picture of the methanol extract (PP-M) of Polygonum plebeium R.Br. and its fractions; hexane (PP-H), ethyl acetate (PP-E) and water (PP-W). In total bioactive component estimation, highest contents of phenolic (89.38±0.27 mgGAE/g extract) and flavonoid (51.21±0.43 mgQE/g extract) were observed in PP-E, and the same fraction exhibited the highest antioxidant potential in DPPH (324.80±4.09 mgTE/g extract), ABTS (563.18±11.39 mgTE/g extract), CUPRAC (411.33±15.49 mgTE/g extract) and FRAC (369.54±1.70 mgTE/g extract) assays. In Phosphomolybdenum activity assay, PP-H and PP-E showed nearly similar potential, however, PP-H was the most active (13.54±0.24 mgEDTAE/g extract) in metal chelating activity assay. PP-W was the stronger inhibitor (4.03±0.05 mgGALAE/g extract) of the enzyme AChE, while PP-H was potent inhibitor of BChE (5.62±0.27 mg GALAE/g extract). Interestingly, PP-E was inactive against BChE. Against tyrosinase activity, PP-E was again the most active fraction with inhibitory value of 71.89±1.44 mg KAE/g extract, followed by the activity of PP-M and PP-W. Antidiabetic potential was almost equally distributed among PP-M, PP-H and PP-E. For mapping the chemodiversity of P. plebeium, PP-M was analyzed through UHPLC/MS, which led to the identification of more than 50 compounds. Flavonoids were the main components derived from isovitexin, kaempferol and luteolin however, gallic acid, protocatechuic acid, gingerols and lyoniresinol 9′-sulfate were among important bioactive phenols. These findings prompted to conclude that Polygonum plebeium can be a significant source to offer new ingredient for nutraceuticals and functional foods.
Yazarlar (10)
1
Muhammad Saleem
2
Natasha Shazmeen
3
Mamona Nazir
4
Naheed Riaz
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
6
Hafiz Muhammad Ataullah
7
Qurat-ul-Ain
8
Farrukh Nisar
9
Mahreen Mukhtar
10
Muhammad Imran Tousif
Anahtar Kelimeler
antioxidant
enzyme inhibition
multivariate analysis
phytochemicals
Polygonum plebeium
UHPLC/MS analysis
Kurumlar
Cholistan University of Veterinary & Animal Sciences, Bahawalpur
Bahawalpur Pakistan
Selçuk Üniversitesi
Selçuklu Turkey
The Government Sadiq College Women University Bahawalpur
Bahawalpur Pakistan
The Islamia University of Bahawalpur
Bahawalpur Pakistan
University of Education
Lahore Pakistan
Metrikler
14
Atıf
10
Yazar
6
Anahtar Kelime