Scopus
🔓 Açık Erişim
LC-MS/HRMS analysis, anti-cancer, anti-enzymatic and anti-oxidant effects of Boerhavia diffusa extracts: A potential raw material for functional applications
Antioxidants · Aralık 2021
Makale Bilgileri
DergiAntioxidants
Yayın TarihiAralık 2021
Cilt / Sayfa10
Scopus ID2-s2.0-85121147814
Erişim🔓 Açık Erişim
Özet
Boerhavia diffusa is a great tropical plant and is widely used for various traditional purposes. In the present study, we examined the influence of solvents (dichloromethane, ethyl acetate, methanol and infusion (water)) on chemical composition and biological capabilities of B. diffusa. An UHPLC-HRMS method was used to determine the chemical characterization. The biological ability was examined for antioxidant, enzyme inhibitory and anti-cancer effects. To evaluate antioxidant effects, different chemical methods (ABTS, DPPH, CUPRAC, FRAP, metal chelating and phosphomolybdenum) were applied. With regard to enzyme inhibitory properties, cholinesterases, amylase, glucosidase and tyrosinase were used. The MDA-MB-231 breast cancer cell line was chosen to determine anticancer activity. Based on the UHPLC-HRMS analysis, 37 specialized metabolites were dereplicated and identified in the studied extracts. Results revealed the presence of 15 hydroxybenzoic, hydroxycinnamic, acylquinic acids, and their glycosides, one rotenoid, seven flavonoids, 12 fatty acids and two other glycosides. Among the tested extracts, the methanol extract showed a stronger antioxidant ability compared with other extracts. The methanol extract also showed the best inhibitory effects on tyrosinase and glucosidase. In the anti-cancer evaluation, the methanol extract showed stronger anticancer effects compared with water extract. In summary, our observations can contribute to the establishment of B. diffusa as a potential candidate for functional applications in the preparation.
Yazarlar (13)
1
Kouadio Ibrahime Sinan
2
Uğur Akpulat
3
Afaf A. Aldahish
4
Yasemin Celik Altunoglu
5
Mehmet Cengiz Baloglu
6
Dimitrina Zheleva-Dimitrova
ORCID: 0000-0002-1952-9903
7
Reneta Gevrenova
ORCID: 0000-0002-1254-2419
8
Devina Lobine
9
Mohamad Fawzi Mahomoodally
10
Ouattara Katinan Etienne
11
Gokhan Zengin
ORCID: 0000-0001-6548-7823
12
Shafi Mahmud
13
Raffaele Capasso
Anahtar Kelimeler
Anti-cancer
Antioxidant
Boerhavia diffusa
Enzyme inhibition
Flavonoids
Functional applications
Kurumlar
Kastamonu University
Kastamonu Turkey
King Khalid University
Abha Saudi Arabia
Medical University of Sofia
Sofia Bulgaria
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Napoli Federico II
Naples Italy
Université de Cocody-Abidjan
Abidjan Cote d'Ivoire
University of Mauritius
Reduit Mauritius
University of Rajshahi
Rajshahi Bangladesh
Metrikler
34
Atıf
13
Yazar
6
Anahtar Kelime