Scopus
YÖKSİS Eşleşti
Comprehensive approaches on chemical composition and biological properties of Daphne pontica L. extracts
Plant Biosystems · Ocak 2022
YÖKSİS Kayıtları
Comprehensive approaches on chemical composition and biological properties of Daphne pontica L. extracts
PLANT BIOSYSTEMS · 2022 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Comprehensive approaches on chemical composition and biological properties of Daphne pontica L. extracts
PLANT BIOSYSTEMS · 2022 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiPlant Biosystems
Yayın TarihiOcak 2022
Cilt / Sayfa156 · 116-129
Scopus ID2-s2.0-85095789869
Özet
The genus Daphne presents great interest as a valuable source of natural agents in traditional medicine of various countries, including Turkey. In the current work, we investigated the phytochemical composition and biological properties of Daphne pontica L. extracts. Methanol extracts of roots, stems and leaves were prepared. The chemical characterization was performed by HPLC-ESI-MSn, observing that flavonoids and phenolic acids were the main compounds. Biological properties were studied in terms of antimicrobial, DNA protection, anticancer, and enzyme inhibitory properties (cholinesterases, tyrosinase, amylase and glucosidase). Methanol extracts of roots, leaves, and stems of D. pontica had antimicrobial effects against a broad range of bacteria. In addition, methanol extract of roots of D. pontica exhibited a promising anticancer activity that was shown to be dose- and time-dependent for HeLa cells with an IC50 value of 203.9 μg/mL. Generally, the leaf extracts exhibited the best enzyme inhibitory properties on the tested enzymes. According to our results, D. pontica might be regarded as a valuable source of natural agents to combat cancer, infectious diseases, and metabolic diseases.
Yazarlar (7)
1
Yasemin Celik Altunoglu
2
Tevfik Hasan Can
ORCID: 0000-0001-8125-4093
3
Enis Fuat Tüfekci
4
Bahattin Deniz Altunoglu
ORCID: 0000-0001-7609-1883
5
Mehmet Cengiz Baloglu
6
E. J. Llorent-Martínez
7
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
anticancer
antimicrobial
Daphne pontica L
enzymes
phenolics
Kurumlar
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Jaén
Jaen Spain
University of Florida Institute of Food and Agricultural Sciences
Gainesville United States
Metrikler
2
Atıf
7
Yazar
5
Anahtar Kelime