Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
An Integrated NMR, LC-DAD-MS, LC-QTOF Metabolomic Characterization of Sartoria hedysaroides: Correlation of Antioxidant and Enzyme Inhibitory Activity with Chemical Composition by Multivariate Data Analysis
Antioxidants · Ocak 2022
YÖKSİS Kayıtları
An Integrated NMR, LC-DAD-MS, LC-QTOF Metabolomic Characterization of Sartoria hedysaroides: Correlation of Antioxidant and Enzyme Inhibitory Activity with Chemical Composition by Multivariate Data Analysis
Antioxidants · 2022 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiAntioxidants
Yayın TarihiOcak 2022
Cilt / Sayfa11
Scopus ID2-s2.0-85122094460
Erişim🔓 Açık Erişim
Özet
Sartoria hedysaroides Boiss and Heldr. (Fabaceae) is an endemic plant of Turkey that has received little scientific consideration so far. In the present study, the chemical profiles of extracts from the aerial part and roots of S. hedysaroides obtained using solvents with different polarities were analyzed combining integrated NMR, LC-DAD-MSn, and LC-QTOF methods. In vitro antioxidant and enzyme inhibitory activities were evaluated, and the results were combined with chemical data using multivariate approaches. Phenolic acids, flavonoids, ellagitannins, and coumarins were identified and quantified in the extracts of aerial part and roots. Methanolic extract of S. hedysaroides aerial part showed the highest phenolic content and the highest antioxidant activity and cupric ion reducing antioxidant capacity. Dichloromethane extract of S. hedysaroides roots showed the highest inhibition of butyryl cholinesterase, while methanolic extract of S. hedysaroides aerial part was the most active tyrosinase inhibitor. Multivariate data analysis allowed us to observe a good correlation between phenolic compounds, especially caffeoylquinic derivatives and flavonoids and the antioxidant activity of extracts. Acetylcholinesterase inhibition was correlated with the presence of caffeoylquinic acids and coumarins. Overall, the present study appraised the biological potential of understudied S. hedysaroides, and provided a comprehensive approach combining metabolomic characterization of plant material and multivariate data analysis for the correlation of chemical data with results from multi-target biological assays.
Yazarlar (9)
1
Stefano Dall'Acqua
2
Stefania Sut
3
Kouadio Ibrahime Sinan
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Irene Ferrarese
6
Gregorio Peron
ORCID: 0000-0002-6007-6184
7
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
8
Carene Marie Nancy Picot-Allain
9
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Antioxidant
Coumarins
Enzyme inhibition
Sartoria
Turkey
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Padova
Padua Italy
University of Mauritius
Reduit Mauritius
Metrikler
2
Atıf
9
Yazar
5
Anahtar Kelime