Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn
Plants · Mart 2022
YÖKSİS Kayıtları
Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn
Plants-Basel · 2022 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiPlants
Yayın TarihiMart 2022
Cilt / Sayfa11
Scopus ID2-s2.0-85125238516
Erişim🔓 Açık Erişim
Özet
Drimia maritima (L.) Stearn (squill), belonging to the Asparagaceae family, is acknowledged as a medicinally valuable species from the Drimia genera. In this study, water, methanol, and ethyl acetate extracts of D. maritima aerial parts and bulbs were investigated for their polyphenols profile and evaluated for their antioxidant and enzyme inhibition properties. Phenolics were profiled through an untargeted metabolomics approach using an ultra-high pressure liquid chromatograph coupled to quadrupole-time-of-flight mass spectrometry (UHPLC-QTOF-MS). This analysis revealed an enrichment of low molecular weight phenolics and flavonoids in the aerial parts of D. maritima, while lignans mainly characterized bulb extracts. Antioxidant capacity was investigated by different assays, including phosphomolybdenum assays, radical scavenging (DPPH: 2,2-diphenyl-1-picrylhydrazyl; ABTS: 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), as well as reducing ability (CUPRAC: cupric reducing antioxidant capacity; FRAP: ferric reducing antioxidant power), and metal chelating. In radical scavenging and reducing power assays, the water extract of aerial parts exhibited the strongest ability (DPPH: 36.99 mg trolox equivalent (TE)/g; ABTS: 85.96 mg TE/g; CUPRAC: 87.37 mg TE/g; FRAP: 55.43 mg TE/g). In general, the ethyl acetate extracts from aerial parts and bulbs provided the weakest antioxidant capacity. Concerning enzyme inhibitory activities, the water extracts of the bulb were poorly active, while the ethyl acetate extracts from both plant portions displayed the best α-amylase inhibitory abilities. The best acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) abilities were recorded by ethyl acetate extract of aerial parts (2.36 mg galantamine equivalent (GALAE)/g) and bulbs (5.10 mg GALAE/g), respectively. Overall, these results support the medicinal aptitude of D. maritima and its possible use as a natural source of antioxidants and enzyme inhibitors with functional potential.
Yazarlar (9)
1
Leilei Zhang
ORCID: 0000-0002-9278-0459
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Mohamad Fawzi Mahomoodally
4
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
5
Sharmeen Jugreet
6
Jesus Simal-Gandara
7
Youssef Rouphael
8
Antonio Pannico
9
Luigi Lucini
ORCID: 0000-0002-5133-9464
Anahtar Kelimeler
Antioxidants
Enzyme inhibition
Metabolomics
Multivariate analysis
Polyphenols
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Universidade de Vigo
Vigo Spain
Università Cattolica del Sacro Cuore, Campus di Piacenza e Cremona
Piacenza Italy
Università degli Studi di Napoli Federico II
Naples Italy
University of Mauritius
Reduit Mauritius
Metrikler
6
Atıf
9
Yazar
5
Anahtar Kelime