Scopus
🔓 Açık Erişim
Chemical Compounds of Berry-Derived Polyphenols and Their Effects on Gut Microbiota, Inflammation, and Cancer
Molecules · Mayıs 2022
Makale Bilgileri
DergiMolecules
Yayın TarihiMayıs 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85130536898
Erişim🔓 Açık Erişim
Özet
Berry-derived polyphenols are bioactive compounds synthesized and secreted by several berry fruits. These polyphenols feature a diversity of chemical compounds, including phenolic acids and flavonoids. Here, we report the beneficial health effects of berry-derived polyphenols and their therapeutical application on gut-microbiota-related diseases, including inflammation and cancer. Pharmacokinetic investigations have confirmed the absorption, availability, and metabolism of berry-derived polyphenols. In vitro and in vivo tests, as well as clinical trials, showed that berry-derived polyphenols can positively modulate the gut microbiota, inhibiting inflammation and cancer development. Indeed, these compounds inhibit the growth of pathogenic bacteria and also promote beneficial bacteria. Moreover, berry-derived polyphenols exhibit therapeutic effects against different gut-microbiota-related disorders such as inflammation, cancer, and metabolic disorders. Moreover, these polyphenols can manage the inflammation via various mechanisms, in particular the inhibition of the transcriptional factor Nf-κB. Berry-derived polyphenols have also shown remarkable effects on different types of cancer, including colorectal, breast, esophageal, and prostate cancer. Moreover, certain metabolic disorders such as diabetes and atherosclerosis were also managed by berry-derived polyphenols through different mechanisms. These data showed that polyphenols from berries are a promising source of bioactive compounds capable of modulating the intestinal microbiota, and therefore managing cancer and associated metabolic diseases. However, further investigations should be carried out to determine the mechanisms of action of berry-derived polyphenol bioactive compounds to validate their safety and examinate their clinical uses.
Yazarlar (14)
1
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
2
Nasreddine El Omari
3
Naoufal El Hachlafi
ORCID: 0000-0003-0768-5914
4
Meryem El Jemly
5
Maryam Hakkour
6
Abdelaali Balahbib
7
Naoual El Menyiy
8
Saad Bakrim
9
Hanae Naceiri Mrabti
10
Aya Khouchlaa
11
Mohamad Fawzi Mahomoodally
12
Michelina Catauro
13
Domenico Montesano
ORCID: 0000-0002-8857-2091
14
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
berries
cancer
gut microbiota
metabolic disorders
polyphenols
Kurumlar
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculté des Sciences Rabat
Rabat Morocco
Mohammed VI University of Sciences and Health - UM6SS
Casablanca Morocco
National Agency of Medicinal and Aromatic Plants
Taounate Morocco
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi della Campania Luigi Vanvitelli
Naples Italy
Università degli Studi di Napoli Federico II
Naples Italy
Université Ibn Zohr
Agadir Morocco
Université Sidi Mohamed Ben Abdellah
Fez Morocco
University of Mauritius
Reduit Mauritius
Metrikler
51
Atıf
14
Yazar
5
Anahtar Kelime