Scopus
🔓 Açık Erişim
Natural Sources, Pharmacological Properties, and Health Benefits of Daucosterol: Versatility of Actions
Applied Sciences (Switzerland) · Haziran 2022
Makale Bilgileri
DergiApplied Sciences (Switzerland)
Yayın TarihiHaziran 2022
Cilt / Sayfa12
Scopus ID2-s2.0-85132272549
Erişim🔓 Açık Erişim
Özet
Daucosterol is a saponin present in various natural sources, including medicinal plant families. This secondary metabolite is produced at different contents depending on species, extraction techniques, and plant parts used. Currently, daucosterol has been tested and explored for its various biological activities. The results reveal potential pharmacological properties such as antioxidant, antidiabetic, hypolipidemic, anti-inflammatory, immunomodulatory, neuroprotective, and anticancer. Indeed, daucosterol possesses important anticancer effects in many signaling pathways, such as an increase in pro-apoptotic proteins Bax and Bcl2, a decrease in the Bcl-2/Bax ratio, upregulation of the phosphatase and tensin homolog (PTEN) gene, inhibition of the PI3K/Akt pathway, and distortion of cell-cycle progression and tumor cell evolution. Its neuroprotective effect is via decreased caspase-3 activation in neurons and during simulated reperfusion (OGD/R), increased IGF1 protein expression (decreasing the downregulation of p-AKT3 and p-GSK-3b4), and activation of the AKT5 signaling pathway. At the same time, daucosterol inhibits key glucose metabolism enzymes to keep blood sugar levels within normal ranges. Therefore, this review describes the principal research on the pharmacological activities of daucosterol and the mechanisms of action underlying some of these effects. Moreover, further investigation of pharmacodynamics, pharmacokinetics, and toxicology are suggested.
Yazarlar (14)
1
Nasreddine El Omari
2
Imane Jouadi
ORCID: 0000-0003-0753-1667
3
Manal Lahyaoui
4
Taoufiq Benali
5
Douae Taha
6
Saad Bakrim
7
Naoual El Menyiy
8
Fatima El Kamari
9
Gokhan Zengin
ORCID: 0000-0001-6548-7823
10
Sneh Punia Bangar
ORCID: 0000-0002-8675-6399
11
José M. Lorenzo
ORCID: 0000-0002-7725-9294
12
Monica Gallo
13
Domenico Montesano
ORCID: 0000-0002-8857-2091
14
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
Anahtar Kelimeler
anticancer
daucosterol
pharmacodynamic
signaling pathways
therapeutic effects
Kurumlar
Clemson University
Clemson United States
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculté des Sciences Rabat
Rabat Morocco
Faculty of Science, Ibn Tofail University
Kenitra Morocco
Fundación Centro Tecnolóxico da Carne
San Cibrao das Vinas Spain
Laboratoire d'Ingénierie des Matériaux Organométalliques et Moléculaires, Université Sidi Mohamed Ben Abdellah
Fez Morocco
Mohammed V University in Rabat
Rabat Morocco
National Agency of Medicinal and Aromatic Plants
Taouanate Morocco
Selçuk Üniversitesi
Selçuklu Turkey
Universidade de Vigo
Vigo Spain
Università degli Studi di Napoli Federico II
Naples Italy
Université Cadi Ayyad
Marakech Morocco
Université Ibn Zohr
Agadir Morocco
Metrikler
20
Atıf
14
Yazar
5
Anahtar Kelime