Scopus
🔓 Açık Erişim
Antioxidant and Enzyme Inhibitory Properties, and HPLC–MS/MS Profiles of Different Extracts of Arabis carduchorum Boiss.: An Endemic Plant to Turkey
Applied Sciences (Switzerland) · Temmuz 2022
Makale Bilgileri
DergiApplied Sciences (Switzerland)
Yayın TarihiTemmuz 2022
Cilt / Sayfa12
Scopus ID2-s2.0-85133420639
Erişim🔓 Açık Erişim
Özet
In this study, six extracts of Arabis carduchorum prepared from solvents of varying polarity (water, methanol, ethyl acetate, dichloromethane, and n‐hexane) were investigated for their chemical profiles and total phenolic and flavonoid contents (TPC/TFC) using HPLC–MS/MS and spectrophotometric/colorimetric assays, respectively, along with the assessment of their antioxidant and enzyme inhibitory effects. In general, the polar extracts (methanol, water, and infusion) showed higher TPC/TFC than the other extracts (range:13.73–26.62 mg GAE/g; 2.66–52.95 mg RE/g, respectively). The total antioxidant capacity of the polar extracts ranged from 0.90–1.85 mmol TE/g in phosphomolybdenum assay, while the free radical scavenging potential ranged from 4.36–32.13 mg TE/g and 12.58–67.73 mg TE/g in DPPH and ABTS assays, respectively. While the water and infuse extract inhibited only butyrylcholinesterase (2.68 and 2.39 mg GALAE/g, respectively), the other extracts were found to inhibit both acetyl‐ and butyryl‐cholinesterases (0.96–2.73 mg GALAE/g and 1.86–5.11 mg GALAE/g, respectively). On the contrary, all extracts exhibited anti‐tyrosinase (40.24– 59.22 mg KAE/g) and anti‐amylase (0.09–0.63 mmol ACAE/g) activities. Overall, this study highlighted the effect of solvent polarity on the extraction of bioactive compounds and the biological properties of the extracts of A. carduchorum; hence, the results obtained could be used to guide optimum extraction in future studies.
Yazarlar (12)
1
Abdullahi Ibrahim Uba
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Domenico Montesano
ORCID: 0000-0002-8857-2091
4
Ugur Cakilcioglu
5
Selami Selvi
6
Musa Denizhan Ulusan
7
Giovanni Caprioli
ORCID: 0000-0002-5530-877X
8
Gianni Sagratini
9
Simone Angeloni
10
Sharmeen Jugreet
11
Mohammad Mehedi Hasan
ORCID: 0000-0002-3871-889X
12
Mohamad Fawzi Mahoomodally
Anahtar Kelimeler
antioxidant
Arabis carduchorum
enzyme inhibition
flavonoids
HPLC–MS/MS
phenolics
solvent polarity
Kurumlar
Balikesir Üniversitesi
Balikesir Turkey
Kadir Has Üniversitesi
Istanbul Turkey
Mawlana Bhashani Science and Technology University
Tangail Bangladesh
Munzur University
Pertek Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Süleyman Demirel Üniversitesi
Isparta Turkey
Università degli Studi di Camerino
Camerino Italy
Università degli Studi di Napoli Federico II
Naples Italy
University of Mauritius
Reduit Mauritius
Metrikler
23
Atıf
12
Yazar
7
Anahtar Kelime