Scopus
🔓 Açık Erişim
Chemical Analysis and Investigation of Biological Effects of Salvia officinalis Essential Oils at Three Phenological Stages
Molecules · Ağustos 2022
Makale Bilgileri
DergiMolecules
Yayın TarihiAğustos 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85136724178
Erişim🔓 Açık Erişim
Özet
Salvia officinalis is a medicinal plant used to treat some diseases, including microbial infections and diabetes. Different studies showed the biological and pharmacological properties of this species. The aim of this study was the determination of the chemical compounds of S. officinalis essential oils and the investigation of their antimicrobial, antioxidant, antidiabetic, and anti-inflammatory properties. The chemical compounds of S. officinalis were determined by GC-MS analysis. The antioxidant activity was assessed by DPPH, ABTS, H2O2, and FRAP assays. The in vitro antidiabetic effect was evaluated by the inhibition of α-amylase, α-glucosidase, and lipase activities, and the anti-inflammatory effect was evaluated using the 5-lipoxygenase assay. Moreover, antibacterial activity was assessed against six bacterial strains using agar well diffusion assay and microdilution method. The main compounds in essential oils of S. officinalis at three phenological stages were naphthalenone, camphor, 1.8-cineole, and α-thujone. The full flowering stage essential oil showed the best antioxidant activity with different IC50 values according to the used tests. This oil also exhibited important inhibitory effects at the full flowering stage against α-amylase (IC50 = 69.23 ± 0.1 μg/mL), α-glucosidase (IC50 = 22.24 ± 0.07 μg/mL), and lipase (IC50 = 37.3 ± 0.03 μg/mL). The 5-lipoxygenase inhibitory effect was the best at the full flowering stage (IC50 = 9.24 ± 0.03 μg/mL). The results of the antibacterial evaluation revealed that, at three seasonal periods, S. officinalis essential oil demonstrated strong antibacterial activity. Although the full flowering stage had the best antibacterial activity, there were no significant differences between the three stages. Additionally, the essential oils showed bactericidal effects on Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis, Proteus mirabilis, Escherichia coli, and Salmonella typhimurium, respectively. The findings of this work showed remarkably that S. officinalis synthesizes essential oils according to different developmental stages. Moreover, it has exhibited interesting biological and pharmacological properties justifying its medicinal effects and suggesting it as a very important source of natural drugs.
Yazarlar (15)
1
Hamza Assaggaf
ORCID: 0000-0001-5563-9491
2
Hanae Naceiri Mrabti
3
Bodour S. Rajab
ORCID: 0000-0002-3874-9434
4
Ammar A. Attar
5
Reema A. Alyamani
6
Munerah Hamed
7
Nasreddine El Omari
8
Naoual El Menyiy
9
Zakaria Hazzoumi
10
Taoufiq Benali
11
Samiah Hamad Al-Mijalli
12
Gokhan Zengin
ORCID: 0000-0001-6548-7823
13
Yusra AlDhaheri
14
Ali H. Eid
15
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
Anahtar Kelimeler
antidiabetic activity
anti-inflammatory effects
essential oils
phenological stages
Salvia officinalis
Kurumlar
College of Medicine
Doha Qatar
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculté des Sciences Rabat
Rabat Morocco
Moroccan Foundation for Advanced Science
Rabat Morocco
National Agency of Medicinal and Aromatic Plants
Taouanate Morocco
Princess Nourah Bint Abdulrahman University
Riyadh Saudi Arabia
Selçuk Üniversitesi
Selçuklu Turkey
Umm Al-Qura University
Makkah Saudi Arabia
United Arab Emirates University
Al Ain United Arab Emirates
Université Cadi Ayyad
Marakech Morocco
Metrikler
21
Atıf
15
Yazar
5
Anahtar Kelime