Scopus
🔓 Açık Erişim
Singular and Combined Effects of Essential Oil and Honey of Eucalyptus Globulus on Anti-Inflammatory, Antioxidant, Dermatoprotective, and Antimicrobial Properties: In Vitro and In Vivo Findings
Molecules · Ağustos 2022
Makale Bilgileri
DergiMolecules
Yayın TarihiAğustos 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85137124834
Erişim🔓 Açık Erişim
Özet
Eucalyptus globulus is a plant widely used by the world population, including Morocco, in the treatment of several pathologies. The aim of this work is to evaluate the antioxidant, anti-inflammatory, dermatoprotective, and antimicrobial effects of essential oil and honey from E. globulus, as well as their combination. Chemical composition was determined by GC-MS analysis. The antioxidant activity was evaluated by three tests, namely, DPPH, reducing power, and the β-carotene/linoleic acid assay. The anti-inflammatory activity was investigated in vitro (5-lipoxygenase inhibition) and in vivo (carrageenan-induced paw edema model), while the dermatoprotective activity was tested in vitro (tyrosinase inhibition). Moreover, the antibacterial activity was assessed using agar well diffusion and microdilution methods. The results showed that eucalyptol presents the main compound of the essential oil of E. globulus (90.14%). The mixture of essential oil with honey showed the best antioxidant effects for all the tests used (0.07 < IC50 < 0.19 mg/mL), while the essential oil was the most active against tyrosinase (IC50 = 38.21 ± 0.13 μg/mL) and 5-lipoxygenase (IC50 = 0.88 ± 0.01 μg/mL), which corroborated the in vivo test. Additionally, the essential oil showed the best bactericidal effects against all strains tested, with inhibition diameter values ranging from 12.8 to 21.6 mm. The findings of this work showed that the combination of the essential oil with honey showed important results in terms of biological activity, but the determination of the underlying mechanisms of action remains a major prospect to be determined.
Yazarlar (15)
1
Hamza Assaggaf
ORCID: 0000-0001-5563-9491
2
Hanae Naceiri Mrabti
3
Bodour S. Rajab
ORCID: 0000-0002-3874-9434
4
Ammar A. Attar
5
Munerah Hamed
6
Ryan A. Sheikh
ORCID: 0000-0003-3275-0861
7
Nasreddine El Omari
8
Naoual El Menyiy
9
Omar Belmehdi
10
Shafi Mahmud
ORCID: 0000-0003-1604-8626
11
Mohammed Merae Alshahrani
ORCID: 0000-0002-9387-5492
12
Moon Nyeo Park
13
Bonglee Kim
ORCID: 0000-0002-8678-156X
14
Gokhan Zengin
ORCID: 0000-0001-6548-7823
15
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
Anahtar Kelimeler
anti-inflammatory
antimicrobial
essential oils
Eucalyptus globulus
honey
Kurumlar
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculté des Sciences Rabat
Rabat Morocco
King Abdulaziz University
Jeddah Saudi Arabia
Kyung Hee University
Seoul South Korea
Najran University
Najran Saudi Arabia
National Agency of Medicinal and Aromatic Plants
Taouanate Morocco
Selçuk Üniversitesi
Selçuklu Turkey
The John Curtin School of Medical Research
Canberra Australia
Umm Al-Qura University
Makkah Saudi Arabia
Université Abdelmalek Essaadi
Tetouan Morocco
Metrikler
12
Atıf
15
Yazar
5
Anahtar Kelime