Scopus
🔓 Açık Erişim
Neuromodulatory and Protective Effects Induced by the Association of Herbal Extracts from Valeriana officinalis, Ziziphus jujuba, and Humulus lupulus with Melatonin: An Innovative Formulation for Counteracting Sleep Disorders
Processes · Ağustos 2022
Makale Bilgileri
DergiProcesses
Yayın TarihiAğustos 2022
Cilt / Sayfa10
Scopus ID2-s2.0-85137600959
Erişim🔓 Açık Erişim
Özet
Background: The use of herbal extracts could represent an advantageous approach for treating sleeping disorders, especially in mild-to-moderate conditions, before the onset of a specific therapy with first-line drugs. Specifically, the focus was posed about the use of extracts from Valeriana officinalis, Ziziphus jujuba, and Humulus lupulus. Multiple studies demonstrated the efficacy of these medicinal plants to positively manage insomnia symptoms. Additionally, their efficacy in the treatment of sleeping disorders could also be improved by their pharmacological association. In the present study, extracts from Valeriana officinalis, Ziziphus jujuba, Humulus lupulus, melatonin, and their pharmacological association, Vagonotte® MEL, were studied for potential application in the treatment of insomnia. Methods: The extracts and melatonin were tested on hypothalamic neurons and tissue for evaluating biocompatibility and protective and neuromodulatory effects. The neuromodulatory effects were evaluated as orexin A gene expression and serotonin steady state level, in the hypothalamus. Results: The extracts and melatonin, although with evident differences, were effective as antioxidant and anti-inflammatory agents; additionally, they were also able to reduce the hypothalamic gene expression of orexin A and the steady state level of serotonin, playing master roles in wakefulness. It is noteworthy that the formulation displayed all the effects of the single ingredients, without any sign of toxicity and pharmacological interference in the hypothalamus. Conclusions: Concluding, the present study explored the biological effects of melatonin and herbal extracts with phytotherapy interest in V. officinalis, Z. jujuba, and H. lupulus. The study demonstrated their intrinsic scavenging/reducing activity, together with protective and neuromodulatory effects in the hypothalamus, with a significant reduction of both orexin A gene expression and serotonin steady state level. Additionally, the study also considered their pharmacological association, which displayed an overall pharmacological spectrum mirroring, including all the effects of the single ingredients, without showing any sign of toxicity in the brain and interference between the extracts and melatonin.
Yazarlar (13)
1
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
2
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
3
Alessandra Acquaviva
4
Nilofar
5
Maria Loreta Libero
ORCID: 0000-0002-8133-5691
6
Luigi Brunetti
7
Lucia Recinella
8
Sheila Leone
9
Giustino Orlando
10
Gokhan Zengin
ORCID: 0000-0001-6548-7823
11
Antonella Mazzone
12
Luigi Menghini
ORCID: 0000-0002-7346-7395
13
Claudio Ferrante
Anahtar Kelimeler
Humulus lupulus
hypothalamus
melatonin
orexin A
oxidative stress
phenolic compounds
serotonin
Valeriana officinalis
Ziziphus jujuba
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
1
Atıf
13
Yazar
9
Anahtar Kelime